Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06651983
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-07
Brief Title:
Association of Inflammatory Factors With Complications in the Diabetic Population a Cross-sectional Study
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Association of Inflammatory Factors With Complications in the Diabetic Population a Cross-sectional Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a cross-sectional study of patients with diabetes The main purpose of this study is to explore the relationship between inflammatory indicators but not limited to inflammatory indicators and diabetes complications in order to find early predictors and screen out high-risk groups
Detailed Description:
Diabetes is one of the most important public health challenges of the 21st century placing a heavy burden on societies and economies The World Health Organization estimates that more than 10 of the worlds population has diabetes or is at high risk of developing it With the change of lifestyle the number of people with diabetes is increasing the types of complications are more and more complicated and the time of complications is more and more earlier Studies have found that the mechanism of diabetes has far exceeded the traditional mechanisms such as insulin resistance and glucose intolerance in the past and the role of chronic low-grade inflammation in the whole course of diabetes should not be underestimated At present more and more researchers have explored the relationship between inflammation and certain clinical outcomes such as diabetes diabetes-related complications hyperlipidemia myocardial infarction stroke aneurysm bladder cancer etc
The study found that people with diabetes had higher levels of inflammation than those without diabetes with a statistically significant difference and among people with diabetes those with severe complications had higher levels of diabetes than those without complications with a statistically significant difference Jiachen Luos study also confirmed that higher SII was associated with a poorer prognosis in patients with diabetes complicated by an acute myocardial infarction event Nayili Mahemuti et al s analysis of NHANES found a positive association between SII and the risk of hyperlipidemia Paul M Ridker also analyzed the participants in the PROMINENT REDUCEIT and STRENGTH trials which included participants who were taking statins and diagnosed with coronary atherosclerosis CRP was found to be significantly associated with the occurrence of several adverse cardiovascular events highest high-sensitive CRP quartile vs lowest high-sensitive CRP quartile adjusted HR 131 95 CI 120-143 P 00001 The body is a complex and complex system with glucose metabolism lipid metabolism inflammatory metabolism and other systems closely related The physiological and pathological changes of diabetes stimulate the activation of chronic low-grade and non-infectious inflammation in the body while long-term inflammatory factors act on various tissues organs and systems of the body which in turn aggravate the occurrence and development of diabetes making diabetes and inflammation cause and effect each other On the basis of traditional inflammatory indicators many new inflammatory indicators have been derived and the relationship between these indicators and clinical outcomes has not been fully explored It is of great significance to investigate the relationship between inflammation and diabetic complications
The study found that people with diabetes had higher levels of inflammation than those without diabetes with a statistically significant difference and among people with diabetes those with severe complications had higher levels of diabetes than those without complications with a statistically significant difference Jiachen Luos study also confirmed that higher SII was associated with a poorer prognosis in patients with diabetes complicated by an acute myocardial infarction event Nayili Mahemuti et al s analysis of NHANES found a positive association between SII and the risk of hyperlipidemia Paul M Ridker also analyzed the participants in the PROMINENT REDUCEIT and STRENGTH trials which included participants who were taking statins and diagnosed with coronary atherosclerosis CRP was found to be significantly associated with the occurrence of several adverse cardiovascular events highest high-sensitive CRP quartile vs lowest high-sensitive CRP quartile adjusted HR 131 95 CI 120-143 P 00001 The body is a complex and complex system with glucose metabolism lipid metabolism inflammatory metabolism and other systems closely related The physiological and pathological changes of diabetes stimulate the activation of chronic low-grade and non-infectious inflammation in the body while long-term inflammatory factors act on various tissues organs and systems of the body which in turn aggravate the occurrence and development of diabetes making diabetes and inflammation cause and effect each other On the basis of traditional inflammatory indicators many new inflammatory indicators have been derived and the relationship between these indicators and clinical outcomes has not been fully explored It is of great significance to investigate the relationship between inflammation and diabetic complications
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None