Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06652763
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2023-11-27
Brief Title:
Manganese-enhanced Magnetic Resonance Imaging MEMRI in Heart Failure With Preserved Ejection Fraction
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Manganese-enhanced Magnetic Resonance Imaging MEMRI in Heart Failure With Preserved Ejection Fraction
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MEMRI in HFpEF
Brief Summary:
Heart failure with preserved ejection fraction HFpEF is a condition in which the heart cannot fill with blood effectively As a result people with HFpEF suffer fatigue breathlessness and develop swollen limbs The condition often requires multiple admissions to hospital and is associated with a marked loss of lifespan
Despite being so common very little is known about why people develop HFpEF and there are hardly any known treatments Type 2 diabetes T2D is a major risk factor for HFpEF and people with both HFpEF and diabetes are at a heightened risk of hospitalisation and premature death It is unclear why the combination of diabetes and HFpEF is particularly harmful This may be related to the hearts of people with type 2 diabetes being unable to take up the mineral calcium properly as well as due to their hearts being less energy efficient Both of these are vital to heart muscle pumping and filling but until recently it has not been possible to assess these in humans
New advances in heart MRI scans with dedicated scanner techniques and dyes manganese contrast now allow extremely detailed pictures of heart structure function calcium uptake and energy efficiency all during the same scan The investigators will enlist 40 volunteers with HFpEF 20 with T2D and 20 without T2D and up to 20 healthy volunteers to undergo a heart MRI scan with manganese contrast to assess calcium uptake and energy efficiency This will allow the comparison of people with HFpEF with and without T2D to see how their hearts are different to healthy volunteers
Despite being so common very little is known about why people develop HFpEF and there are hardly any known treatments Type 2 diabetes T2D is a major risk factor for HFpEF and people with both HFpEF and diabetes are at a heightened risk of hospitalisation and premature death It is unclear why the combination of diabetes and HFpEF is particularly harmful This may be related to the hearts of people with type 2 diabetes being unable to take up the mineral calcium properly as well as due to their hearts being less energy efficient Both of these are vital to heart muscle pumping and filling but until recently it has not been possible to assess these in humans
New advances in heart MRI scans with dedicated scanner techniques and dyes manganese contrast now allow extremely detailed pictures of heart structure function calcium uptake and energy efficiency all during the same scan The investigators will enlist 40 volunteers with HFpEF 20 with T2D and 20 without T2D and up to 20 healthy volunteers to undergo a heart MRI scan with manganese contrast to assess calcium uptake and energy efficiency This will allow the comparison of people with HFpEF with and without T2D to see how their hearts are different to healthy volunteers
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None