Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06654206
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-21
Brief Title:
Effects of a Strength Physical Exercise Program in Chronic Lymphocytic Leukemia Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
EFFECTS of a THERAPEUTIC STRENGTH EXERCISE PROGRAM on the FUNCTIONAL CAPACITY PSYCHOSOCIAL FACTORS and QUALITY of LIFE of PATIENTS with CHRONIC LYMPHOCYTIC LEUKEMIA
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic lymphocytic leukemia CLL is a hematological neoplasm that primarily affects older individuals and is the most common type of leukemia in adults in Western countries CLL mainly affects older adults with an average age at diagnosis of around 70 years and there is a slightly higher risk in men compared to women It is characterized by the proliferation of clonal B lymphocytes in peripheral blood bone marrow and lymphoid organs Although CLL has a relatively slow progression in many cases patients may experience chronic fatigue muscle weakness functional impairment and psychological disorders such as anxiety and depression which significantly affect their quality of life
In this context it has been shown that physical exercise especially strength training can considerably improve physical and psychological conditions in oncology populations such as those with breast cancer and colorectal cancer as well as in older adults where the benefits of resistance training are widely recognized These benefits include increased muscle strength reduced fatigue improved functional abilities psychological well-being and overall quality of life Furthermore there is evidence that exercise can reduce systemic inflammatory markers such as C-reactive protein CRP and improve lipid profiles by lowering total cholesterol and triglycerides which is crucial for cancer patients at risk of cardiovascular diseases
In this context it has been shown that physical exercise especially strength training can considerably improve physical and psychological conditions in oncology populations such as those with breast cancer and colorectal cancer as well as in older adults where the benefits of resistance training are widely recognized These benefits include increased muscle strength reduced fatigue improved functional abilities psychological well-being and overall quality of life Furthermore there is evidence that exercise can reduce systemic inflammatory markers such as C-reactive protein CRP and improve lipid profiles by lowering total cholesterol and triglycerides which is crucial for cancer patients at risk of cardiovascular diseases
Detailed Description:
Aquí tienes la traducción al inglés
Current research on the effects of physical exercise in patients with CLL is limited While some studies suggest that cancer patients may benefit from physical exercise most research has focused on other types of cancer such as breast lung or colorectal cancer In the case of patients with CLL in addition to functional and psychological issues they often experience chronic inflammation and alterations in lipid profiles which can increase the risk of cardiovascular comorbidities
Inflammatory markers such as C-reactive protein CRP and pro-inflammatory cytokines IL-6 TNF-α are common in patients with CLL and it has been suggested that modulating these markers through exercise may help control systemic inflammation Strength training in particular could be beneficial for improving the inflammatory and lipid profiles in these patients although this has not been thoroughly evaluated in this population
Regarding mental health studies have reported that patients with CLL experience high levels of anxiety and depression which significantly deteriorate their quality of life In other oncology populations exercise has proven effective in reducing these symptoms and improving overall well-being However it has not been sufficiently studied whether these effects can be replicated in patients with CLL representing a gap in the current literature
Finally the loss of muscle strength a key indicator in the diagnosis of sarcopenia according to the diagnostic algorithm proposed by the European Working Group on Sarcopenia in Older People in 2019 EWGSOP2 should be considered another common issue in patients with CLL due to both the average age of the patients 70 years and the disease itself or the side effects of treatment Although it has been shown that physical exercise in general and strength exercise in particular can improve muscle strength and functional capacity in older adults and cancer patients studies evaluating these effects in patients with CLL are lacking Assessing how a strength training program can influence functional recovery and improve the quality of life of these patients is crucial for their clinical management
Current research on the effects of physical exercise in patients with CLL is limited While some studies suggest that cancer patients may benefit from physical exercise most research has focused on other types of cancer such as breast lung or colorectal cancer In the case of patients with CLL in addition to functional and psychological issues they often experience chronic inflammation and alterations in lipid profiles which can increase the risk of cardiovascular comorbidities
Inflammatory markers such as C-reactive protein CRP and pro-inflammatory cytokines IL-6 TNF-α are common in patients with CLL and it has been suggested that modulating these markers through exercise may help control systemic inflammation Strength training in particular could be beneficial for improving the inflammatory and lipid profiles in these patients although this has not been thoroughly evaluated in this population
Regarding mental health studies have reported that patients with CLL experience high levels of anxiety and depression which significantly deteriorate their quality of life In other oncology populations exercise has proven effective in reducing these symptoms and improving overall well-being However it has not been sufficiently studied whether these effects can be replicated in patients with CLL representing a gap in the current literature
Finally the loss of muscle strength a key indicator in the diagnosis of sarcopenia according to the diagnostic algorithm proposed by the European Working Group on Sarcopenia in Older People in 2019 EWGSOP2 should be considered another common issue in patients with CLL due to both the average age of the patients 70 years and the disease itself or the side effects of treatment Although it has been shown that physical exercise in general and strength exercise in particular can improve muscle strength and functional capacity in older adults and cancer patients studies evaluating these effects in patients with CLL are lacking Assessing how a strength training program can influence functional recovery and improve the quality of life of these patients is crucial for their clinical management
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None