Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06654908
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-14
Brief Title:
Insulin Resistance and Resisted Exercise Post Burn
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Insulin Resistance and Resisted Exercise Post Burn
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main objective of the present study is to assess the effect of the resisted exercise on insulin resistance post burn
Detailed Description:
A burn injury represents the fourth most common type of trauma globally though it is associated with the most devastating consequences Severe burn injuries encompassing 20 of the total body surface area TBSA in adults present a unique challenge compared with other forms of trauma given the magnitude and persistence of systemic deregulation Indeed an extensive inflammatory response develops immediately following a severe burn to promote wound healing This period known as the ebb phase is comparable with a fight-or-flight response and lasts for the first 72-96 h post injury
Moreover burn-induced muscle catabolism places a significant burden on the recovery process as a 10-30 loss impairs immune responses and delays wound healing thereby increasing the risk of infection and a 40 loss becomes fatal Despite a mountainous effort to prevent muscle catabolism and wasting Therefore a better understanding of the pathophysiology and consequences of burn-induced skeletal muscle wasting is pivotal to alleviating hyper metabolism and reducing morbidity and mortality patients with severe burns
Hence extensive burn injury produce clinical syndromes characterized in part by insulin resistance it is unclear if these insulin resistant states are identical To test if the maximal biological effectiveness of insulin is altered in burned patients
Moreover burn-induced muscle catabolism places a significant burden on the recovery process as a 10-30 loss impairs immune responses and delays wound healing thereby increasing the risk of infection and a 40 loss becomes fatal Despite a mountainous effort to prevent muscle catabolism and wasting Therefore a better understanding of the pathophysiology and consequences of burn-induced skeletal muscle wasting is pivotal to alleviating hyper metabolism and reducing morbidity and mortality patients with severe burns
Hence extensive burn injury produce clinical syndromes characterized in part by insulin resistance it is unclear if these insulin resistant states are identical To test if the maximal biological effectiveness of insulin is altered in burned patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None