Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06656767
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-10-16
Brief Title:
Somatic Mutation in Chronic Liver Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Understanding the Evolution of the Somatic Mutational Landscape in Chronic Liver Disease Across Aetiologies and Disease States
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Deaths from chronic liver disease are rising in the UK and around the world The leading causes are alcohol-related liver disease metabolic-dysfunction associated steatotic liver disease MASLD formerly known as non-alcoholic fatty liver disease and viral hepatitis Chronic liver disease puts people at significantly increased risk of liver cancer which in the UK has a 5 year survival of under 15 Little is understood about how liver cells acquire genetic changes called somatic mutations as they progress from healthy cells to disease to cancer development This study aims to investigate these somatic mutations across different causes of chronic liver disease and different stages of liver disease The investigators hope this will help us to understand how different insults to the liver put the liver cells under different pressures resulting in varying genetic changes By understanding these changes specific to disease aetiology and stage novel genetic targets may be identified which assist to focus research in identifying specific prognostic diagnostic and therapeutic tools in chronic liver disease and improve outcomes for patients
Tissue surplus to clinical requirement from patients were undergoing liver biopsy liver resection or liver transplantation tissue sampling from explanted liver collected by collaborators at University of Texas Southwestern will undergo genomic sequencing at the Wellcome Sanger Institute
Tissue surplus to clinical requirement from patients were undergoing liver biopsy liver resection or liver transplantation tissue sampling from explanted liver collected by collaborators at University of Texas Southwestern will undergo genomic sequencing at the Wellcome Sanger Institute
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None