Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06657300
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-10-23
Brief Title:
Assessment and Comparison of Efficacy of Intra-Articular PRP and Corticosteroid in First CMC Joint OA Treatment
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessment and Comparison of Efficacy of Intra-Articular Platelet Rich Plasma and Corticosteroid on Pain Hand Function and Pinch Strength in First Carpometacarpal Joint Osteoarthritis Treatment a Randomized Prospective Double-blind Clinical Trial
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aim We aim to determine and compare the efficiency of single dose intra-articular IA platelet rich plasma PRP and corticosteroid CS injections for the treatment of first carpometacarpal joint osteoarthritis 1 CMC OA on the basis of pain hand function and pinch strength
Material and Method Sixty patients meeting the criteria were included in the study Patients were randomized into Group 1 PRP group or Group 2 CS group Patients were evaluated by Visual Analogue Scale VAS Duruoz Hand Index DHI and pinch meter for pain and function
Material and Method Sixty patients meeting the criteria were included in the study Patients were randomized into Group 1 PRP group or Group 2 CS group Patients were evaluated by Visual Analogue Scale VAS Duruoz Hand Index DHI and pinch meter for pain and function
Detailed Description:
OsteoarthritisOA which is the most prevalent form of arthritis is a degenerative process eroding articular cartilage Joints affected most commonly include hand knee hip and spineThe trapeziometacarpal joint of the thumb CMC is a common source of pain due to OA Age adjusted prevalence of rhizarthrosis is reported as 5-17 in men and 7-21 in women Although the effect of the CMC osteoarthritis rhizarthrosis on hand function and strength have been reported it is likely underdiagnosed in clinical practice Conservative treatment modalities range from therapy orthoses modification of daily activities to intraarticular injection in early stages For patients who fail conservative measures or advanced stages surgical treatment options are indicated
Platelet-rich plasma PRP is the processed fraction of autologous peripheral blood with a platelet concentration above the baseline PRP therapies have been used in the treatment of dejenerative joint disease and also in different fields of medicine for more than two decades The rationale underlying the PRP therapy in OA is to stimulate the tissue repair and regeneration via growth factors and bioactive molecules involved in basic pathways such as inflammation angiogenesis and cell migration in alpha granules of platelets The studies evaluating the theuropatic effect of PRP in osteoarthritis generally include its application in the knee hip and shoulder joints There is very few article reporting the application of PRP in rhizarthrosis
2019 American College of RheumatologyArthritis Foundation Guideline for the Management of Osteoarthritis of the Hand Hip and Knee suggests no recommendation in regard to osteoarthritis of the hand Same guideline suggest that intraarticular glucocorticoid injection is conditionally rather than strongly recommended for hand osteoarthritis In 2018 update of the EULAR recommendation fort he management of hand osteoarthritis did not mention the PRP application for hand osteoarthritis
In our prospective randomised double-blind clinical study we aimed to compare the results of the intraarticular application of corticosteroid and PRP in early stages of the rhizarthrosis
Platelet-rich plasma PRP is the processed fraction of autologous peripheral blood with a platelet concentration above the baseline PRP therapies have been used in the treatment of dejenerative joint disease and also in different fields of medicine for more than two decades The rationale underlying the PRP therapy in OA is to stimulate the tissue repair and regeneration via growth factors and bioactive molecules involved in basic pathways such as inflammation angiogenesis and cell migration in alpha granules of platelets The studies evaluating the theuropatic effect of PRP in osteoarthritis generally include its application in the knee hip and shoulder joints There is very few article reporting the application of PRP in rhizarthrosis
2019 American College of RheumatologyArthritis Foundation Guideline for the Management of Osteoarthritis of the Hand Hip and Knee suggests no recommendation in regard to osteoarthritis of the hand Same guideline suggest that intraarticular glucocorticoid injection is conditionally rather than strongly recommended for hand osteoarthritis In 2018 update of the EULAR recommendation fort he management of hand osteoarthritis did not mention the PRP application for hand osteoarthritis
In our prospective randomised double-blind clinical study we aimed to compare the results of the intraarticular application of corticosteroid and PRP in early stages of the rhizarthrosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None