Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001977
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-01-20
Brief Title:
The Effect of Acetylcholine on Memory and Attention
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Cholinergic Modulation of Human Memory and Attention Functional Neuroimaging Studies
Status:
COMPLETED
Status Verified Date:
2000-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine whether enhancing the chemical acetylcholine in the brain can improve memory and attention It will identify changes in brain function that occur during these cognitive tasks Animal and human studies have shown that a decrease in acetylcholine may be responsible for some of the cognition deficits in Alzheimers disease Conversely patients taking medications that slow the breakdown of this neurotransmitter have experienced improvements in memory
Normal volunteers and patients with Alzheimers disease may be eligible for this study of functional brain imaging using positron emission tomography PET and magnetic resonance imaging MRI These techniques can measure brain activity and identify brain regions involved in memory and attention Candidates for this study will be screened with a medical and psychiatric history and a physical examination including blood tests urinalysis chest X-ray and electrocardiogram ECG Those enrolled will perform memory and attention tasks during PET and MRI studies The cognition tasks will be repeated twice-once during infusion of saline a fluid with no drug effect through a catheter inserted into a blood vessel and again during infusion of physostigmine a drug that delays the breakdown of acetylcholine The PET procedure will be completed in one day the MRI procedure will be done on two different days
During imaging attention and memory tasks will be presented in short blocks of about 4-minutes duration They will be repeated in sequence up to 10 times with a few minutes separation Subjects will be shown pictures of faces or other visual stimuli and asked to decide whether the pictures are the same or different
Information gained from this study may increase knowledge about how acetylcholine affects the brains response to memory and attention tasks and perhaps lead to better treatments for the cognitive deficits in Alzheimers disease
Normal volunteers and patients with Alzheimers disease may be eligible for this study of functional brain imaging using positron emission tomography PET and magnetic resonance imaging MRI These techniques can measure brain activity and identify brain regions involved in memory and attention Candidates for this study will be screened with a medical and psychiatric history and a physical examination including blood tests urinalysis chest X-ray and electrocardiogram ECG Those enrolled will perform memory and attention tasks during PET and MRI studies The cognition tasks will be repeated twice-once during infusion of saline a fluid with no drug effect through a catheter inserted into a blood vessel and again during infusion of physostigmine a drug that delays the breakdown of acetylcholine The PET procedure will be completed in one day the MRI procedure will be done on two different days
During imaging attention and memory tasks will be presented in short blocks of about 4-minutes duration They will be repeated in sequence up to 10 times with a few minutes separation Subjects will be shown pictures of faces or other visual stimuli and asked to decide whether the pictures are the same or different
Information gained from this study may increase knowledge about how acetylcholine affects the brains response to memory and attention tasks and perhaps lead to better treatments for the cognitive deficits in Alzheimers disease
Detailed Description:
The goal of this research project is to determine the role of cholinergic neuromodulation in the functional organization of memory and attention in humans using functional neuroimaging techniques The study of human cognition with functional brain imaging in conjunction with pharmacologic probes that alter cognitive processes provides an opportunity to examine another dimension of the organization of human neural systems In addition to identifying the anatomical structures that participate in specific cognitive functions this approach can reveal how different neuromodulators can influence processing in those structures Additionally the combined use of functional brain imaging and pharmacological manipulation can be used to evaluate the role of neurotransmitter dysfunction in disease states that produce cognitive impairment and may direct us to potential therapeutic approaches
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-M-0056 | None | None | None |