Ignite Creation Date:
2025-12-18 @ 9:12 AM
Ignite Modification Date:
2025-12-23 @ 8:46 PM
Study NCT ID:
NCT00809549
Status:
None
Last Update Posted:
2012-07-13 00:00:00
First Post:
2008-10-17 00:00:00
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Study to Determine The Effect of a Drug Called Neupogen on Stroke Recovery
Sponsor:
None
Organization:
Study Overview
Official Title:
Granulocyte-Colony Stimulating Factor In Ischemic Stroke (GIST): A Pilot Study
Status:
None
Status Verified Date:
2012-07
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GIST
Brief Summary:
We hypothesize that mobilization of bone marrow precursor cells into the blood stream will allow them to redistribute in the injured central nervous system and aid regeneration of damaged tissue. If the hypotheses is correct, it predicts that G-CSF treatment will improve the functional outcome of patients following acute ischemic stroke.
Underlying this work are the following considerations:
* Currently the clinical and functional outcomes following ischemic strokes are poor and require new treatment strategies.
* G-CSF administration is a well established routine treatment for the mobilization of hematopoietic and endothelial precursors from the bone marrow into the circulation.
* Acute ischemia locally increases factors that direct circulating bone marrow derived cells to home to these sites of injury.
* Evidence exists that bone marrow derived cells are able to repopulate different tissues including those of the CNS.
* Acute ischemic injury to the central nervous system provides a milieu for the regeneration of neural tissue.
Underlying this work are the following considerations:
* Currently the clinical and functional outcomes following ischemic strokes are poor and require new treatment strategies.
* G-CSF administration is a well established routine treatment for the mobilization of hematopoietic and endothelial precursors from the bone marrow into the circulation.
* Acute ischemia locally increases factors that direct circulating bone marrow derived cells to home to these sites of injury.
* Evidence exists that bone marrow derived cells are able to repopulate different tissues including those of the CNS.
* Acute ischemic injury to the central nervous system provides a milieu for the regeneration of neural tissue.
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: