Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005236
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Atherosclerosis and Omega-3 Fatty Acids in Alaskan Natives
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether there were differences in the prevalence and extent of atherosclerotic lesions in the coronaries and aortas between Alaskan natives and non-natives and whether the extent of the lesions was related to omega-3 fatty acids in blood and tissues
Detailed Description:
BACKGROUND
Purported low mortality from coronary heart disease in Eskimos from Greenland Canada or Alaska has been interpreted by many investigators as synonymous with the absence of or reduced amount of atherosclerotic lesions in the coronary arteries compared to populations with a high rate of coronary heart disease It was thought that this study would help to clarify the role of omega-3 fatty acids in atherosclerosis but also would help in making a decision whether to recommend to the general public the inclusion of fish oils which contain large amounts of these fatty acids in the diet for prevention andor reduction of atherosclerotic heart disease
DESIGN NARRATIVE
Coronary arteries aortas blood adipose tissue and liver were collected at autopsy from deceased Alaskan natives aged 5 years and above dying of all causes and from a similar number of age- and sex-matched non-native Alaskans Tested standardized methods of gross evaluation histomorphometry and chemistry were used to characterize measure and evaluate the prevalence and extent of atherosclerosis in arteries Chemical methods for determination of blood and tissue lipids and gas liquid chromatographic methods for determination of fatty acids in various lipid fractions in plasma and tissues were used Risk factors for coronary artery disease were evaluated from tissues taken at autopsy Hypertension was evaluated by an examination of kidney arterioles Cigarette smoking was evaluated by measurement of thiocyanate in the blood and the presence or absence of diabetes was evaluated by measuring glycosylation of hemoglobin from red blood cells Findings were compared with those studied in other populations such as Blacks and whites in New Orleans and Japanese Norwegians and nineteen other ethnic groups in the International Atherosclerosis Project
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Purported low mortality from coronary heart disease in Eskimos from Greenland Canada or Alaska has been interpreted by many investigators as synonymous with the absence of or reduced amount of atherosclerotic lesions in the coronary arteries compared to populations with a high rate of coronary heart disease It was thought that this study would help to clarify the role of omega-3 fatty acids in atherosclerosis but also would help in making a decision whether to recommend to the general public the inclusion of fish oils which contain large amounts of these fatty acids in the diet for prevention andor reduction of atherosclerotic heart disease
DESIGN NARRATIVE
Coronary arteries aortas blood adipose tissue and liver were collected at autopsy from deceased Alaskan natives aged 5 years and above dying of all causes and from a similar number of age- and sex-matched non-native Alaskans Tested standardized methods of gross evaluation histomorphometry and chemistry were used to characterize measure and evaluate the prevalence and extent of atherosclerosis in arteries Chemical methods for determination of blood and tissue lipids and gas liquid chromatographic methods for determination of fatty acids in various lipid fractions in plasma and tissues were used Risk factors for coronary artery disease were evaluated from tissues taken at autopsy Hypertension was evaluated by an examination of kidney arterioles Cigarette smoking was evaluated by measurement of thiocyanate in the blood and the presence or absence of diabetes was evaluated by measuring glycosylation of hemoglobin from red blood cells Findings were compared with those studied in other populations such as Blacks and whites in New Orleans and Japanese Norwegians and nineteen other ethnic groups in the International Atherosclerosis Project
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL042082 | NIH | None | httpsreporternihgovquickSearchR01HL042082 |