Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00008541
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2001-01-13
Brief Title:
Evaluation and Treatment of Patients With Corneal and External Diseases
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Evaluation and Treatment of Corneal and External Diseases and Anterior Segment Disorders
Status:
COMPLETED
Status Verified Date:
2009-03-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study offers evaluation and treatment for patients with certain corneal and external diseases of the eye diseases of the surface of the eye and its surrounding structures The protocol is not designed to test new treatments rather patients will receive current standard of care treatments The purpose of the study is twofold 1 to allow National Eye Institute physicians to increase their knowledge of various corneal and external conditions and identify possible new avenues of research in this area and 2 to establish a pool of patients who may be eligible for new studies as they are developed Participants in this protocol will not be required to join a new study the decision will be voluntary
Children and adults with corneal or external eye diseases may be eligible for this study Candidates will be screened with a medical history brief physical examination thorough eye examination and blood test The eye examination includes measurements of eye pressure and visual acuity ability to see the vision chart and dilation of the pupils to examine the lens and retina back part of the eye Patients will also undergo the following procedures
1 Eye photography - Special photographs of the inside of the eye to help evaluate the status of the cornea and conjunctiva the most superficial layer of the eye evaluate changes that may occur in the future From two to 20 pictures may be taken depending on the eye condition The camera flashes a bright light into the eye for each picture
2 Conjunctival or lacrimal gland biopsy - A small piece of the conjunctiva or the lacrimal tear gland is removed for examination under the microscope Anesthetic drops and possibly an injection of anesthetic are given to numb the eye An antibiotic ointment and patch may be placed over the eye for several hours after the procedure
Participants will be followed at least 3 years Follow-up visits are scheduled according to the standard of care for the individual patients eye problem Vision will be checked at each visit and some of the tests described above may be repeated to follow the progress of disease and evaluate the response to any treatment that is given
Children and adults with corneal or external eye diseases may be eligible for this study Candidates will be screened with a medical history brief physical examination thorough eye examination and blood test The eye examination includes measurements of eye pressure and visual acuity ability to see the vision chart and dilation of the pupils to examine the lens and retina back part of the eye Patients will also undergo the following procedures
1 Eye photography - Special photographs of the inside of the eye to help evaluate the status of the cornea and conjunctiva the most superficial layer of the eye evaluate changes that may occur in the future From two to 20 pictures may be taken depending on the eye condition The camera flashes a bright light into the eye for each picture
2 Conjunctival or lacrimal gland biopsy - A small piece of the conjunctiva or the lacrimal tear gland is removed for examination under the microscope Anesthetic drops and possibly an injection of anesthetic are given to numb the eye An antibiotic ointment and patch may be placed over the eye for several hours after the procedure
Participants will be followed at least 3 years Follow-up visits are scheduled according to the standard of care for the individual patients eye problem Vision will be checked at each visit and some of the tests described above may be repeated to follow the progress of disease and evaluate the response to any treatment that is given
Detailed Description:
This protocol will permit the specialists in cornea and external disease at the NEI to identify follow and provide standard of care treatment to patients with various corneal and external disease and anterior segment disorders By providing long-term follow-up and treatment for a variety of corneal and external diseases the corneal specialists at NEI will be better able to identify research hypotheses about these diseases in addition to maintaining their clinical skills Another purpose of the protocol is to accumulate a cohort of patients with corneal diseases for possible participation in new NEI clinical trials and epidemiological protocols The availability of cohorts of patients with a spectrum of anterior segment diseases will be valuable for the training of fellows an important component of the mission of the NEI The ability to provide follow-up and care will also facilitate referral efforts for NEI protocols
The cornea specialists at the National Eye Institute will be free to choose those conditions that interest them However the total number of patients that can be enrolled in the protocol will be restricted This protocol is not designed to test any new treatments Any evaluations or treatment under this protocol will be based on the current standard of care as appropriate for the relevant ocular disease
Participants in this evaluation and treatment protocol will be evaluated for potential eligibility in other NEI clinical trials or epidemiologic protocols as they are developed If eligible they may be asked to participate in the new protocol however they will not be required to enter any protocol and their decision to participate will be entirely voluntary
The cornea specialists at the National Eye Institute will be free to choose those conditions that interest them However the total number of patients that can be enrolled in the protocol will be restricted This protocol is not designed to test any new treatments Any evaluations or treatment under this protocol will be based on the current standard of care as appropriate for the relevant ocular disease
Participants in this evaluation and treatment protocol will be evaluated for potential eligibility in other NEI clinical trials or epidemiologic protocols as they are developed If eligible they may be asked to participate in the new protocol however they will not be required to enter any protocol and their decision to participate will be entirely voluntary
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-EI-0046 | None | None | None |