Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001325
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Metabolic Abnormalities in Children With Epilepsy
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Natural History of Metabolic Abnormalities in Children With Epilepsy
Status:
COMPLETED
Status Verified Date:
2004-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to use positron emission tomography to measure brain energy use Positron Emission Tomography PET is a technique used to investigate the functional activity of the brain The PET technique allows doctors to study the normal processes of the brain central nervous system of normal individuals and patients with neurologic illnesses without physical structural damage to the brain
When a region of the brain is active it uses more fuel in the form of oxygen and sugar glucose As the brain uses more fuel it produces more waste products carbon dioxide and water Blood carries fuel to the brain and waste products away from the brain As brain activity increases blood flow to and from the area of activity increases also
Researchers can label a sugar with a small radioactive molecule called FDG fluorodeoxyglucose As areas of the brain use more sugar the PET scan will detect the FDG and show the areas of the brain that are active By using this technique researchers hope to answer the following questions
4 Are changes in brain energy use metabolism present early in the course of epilepsy
5 Do changes in brain metabolism match the severity of patients seizures
6 Do changes in metabolism occur over time or in response to drug therapy
When a region of the brain is active it uses more fuel in the form of oxygen and sugar glucose As the brain uses more fuel it produces more waste products carbon dioxide and water Blood carries fuel to the brain and waste products away from the brain As brain activity increases blood flow to and from the area of activity increases also
Researchers can label a sugar with a small radioactive molecule called FDG fluorodeoxyglucose As areas of the brain use more sugar the PET scan will detect the FDG and show the areas of the brain that are active By using this technique researchers hope to answer the following questions
4 Are changes in brain energy use metabolism present early in the course of epilepsy
5 Do changes in brain metabolism match the severity of patients seizures
6 Do changes in metabolism occur over time or in response to drug therapy
Detailed Description:
We propose to study children with recent onset partial epilepsy cryptogenic infantile spasms and idiopathic Lennox-Gastaut Syndrome with serial FDG-PET to elucidate the natural history and evolution of metabolic abnormalities associated with such epilepsies The severity of the seizure disorder and cognitive impairment when present will be correlated with the presence and extent of focal and global cerebral metabolic abnormalities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-N-0175 | None | None | None |