Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005257
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Diet and Plasma Cholesterol - Secular Trend Analysis
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To define the role of dietary variables on changes in plasma cholesterol levels over time in the Framingham cohort and the Framingham Offspring cohort
Detailed Description:
BACKGROUND
Mortality from coronary heart disease has declined over 40 percent since the late 1960s Possible explanations for the decline include the observed trends in risk factors such as changes in rates of hypertension dyslipidemia and glucose intolerance lifestyle changes such as improvements in diet and decreases in the levels of cigarette smoking and better detection and treatment of heart disease The specific effects of risk factor lifestyle or detection and treatment changes on the declining population rates of coronary heart disease morbidity and mortality were unknown in 1990 Secular trend analyses were needed to elucidate the relative contribution of these factors particularly dietary variables on population rates of coronary heart disease
DESIGN NARRATIVE
Multiple regression was used to assess the effect of dietary variables on changes in serum cholesterol between 1957-1960 and 1966-1969 in a sample of 200 men for whom repeated measurements existed in the Framingham cohort Analysis of covariance was used to assess influence of dietary intake on differences in serum cholesterol levels between independent samples of men studied in 1957-1960 and 1966-1969 in the Framingham cohort and independent samples of women studied between 1957-1960 and 1984-1988 in the Framingham cohort and Offspring cohort and independent samples of men studied between 1966-1969 and 1984-1988 in the Framingham cohort and Offspring cohorts respectively
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Mortality from coronary heart disease has declined over 40 percent since the late 1960s Possible explanations for the decline include the observed trends in risk factors such as changes in rates of hypertension dyslipidemia and glucose intolerance lifestyle changes such as improvements in diet and decreases in the levels of cigarette smoking and better detection and treatment of heart disease The specific effects of risk factor lifestyle or detection and treatment changes on the declining population rates of coronary heart disease morbidity and mortality were unknown in 1990 Secular trend analyses were needed to elucidate the relative contribution of these factors particularly dietary variables on population rates of coronary heart disease
DESIGN NARRATIVE
Multiple regression was used to assess the effect of dietary variables on changes in serum cholesterol between 1957-1960 and 1966-1969 in a sample of 200 men for whom repeated measurements existed in the Framingham cohort Analysis of covariance was used to assess influence of dietary intake on differences in serum cholesterol levels between independent samples of men studied in 1957-1960 and 1966-1969 in the Framingham cohort and independent samples of women studied between 1957-1960 and 1984-1988 in the Framingham cohort and Offspring cohort and independent samples of men studied between 1966-1969 and 1984-1988 in the Framingham cohort and Offspring cohorts respectively
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL043919 | NIH | None | httpsreporternihgovquickSearchR01HL043919 |