Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001845
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Study of Brain Blood Flow During Induced Hypercapnia Excess Blood Carbon Dioxide
Sponsor:
National Institutes of Health Clinical Center CC
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
MR Perfusion Imaging in Hypercapnia Development of Technical Protocols
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate magnetic resonance imaging MRI methods for measuring changes in the brains blood flow during hypercapnia a condition of excess carbon dioxide in the blood MRI is a diagnostic tool that uses a large magnet and radio waves to produce images of the body without X-rays
Healthy normal volunteers in this study may have as many as six MRI scans over a 2-year period For this procedure the person lies on a stretcher placed in a strong magnetic field produced by the MRI machine During the scan the persons blood carbon dioxide CO2 levels will be increased either by 1 breathing air mixtures containing up to 5 CO2 or 2 receiving an intravenous IV injection of a drug called acetazolamide
Persons who breathe CO2 will have their heart rate blood pressure and oxygen levels monitored throughout the procedure Those receiving acetazolamide will have the drug injected intravenously IV into an arm vein If the volunteer experiences any unpleasant side effects from the CO2 or acetazolamide the study will be stopped
The information gained from this study will be used to develop better ways to study brain function possibly leading to better diagnostic and treatment methods
Healthy normal volunteers in this study may have as many as six MRI scans over a 2-year period For this procedure the person lies on a stretcher placed in a strong magnetic field produced by the MRI machine During the scan the persons blood carbon dioxide CO2 levels will be increased either by 1 breathing air mixtures containing up to 5 CO2 or 2 receiving an intravenous IV injection of a drug called acetazolamide
Persons who breathe CO2 will have their heart rate blood pressure and oxygen levels monitored throughout the procedure Those receiving acetazolamide will have the drug injected intravenously IV into an arm vein If the volunteer experiences any unpleasant side effects from the CO2 or acetazolamide the study will be stopped
The information gained from this study will be used to develop better ways to study brain function possibly leading to better diagnostic and treatment methods
Detailed Description:
Advances in MR perfusion imaging have provided clinical researchers with the opportunity to quantitate regional increases in cerebral blood flow The purpose of this study is to acquire the technical experience required to perform MR perfusion imaging studies of the hypercapnic cerebral blood flow response Cerebral blood flow will be increased by inhalation of carbogen an air mixture containing 5 CO2 or IV injection of the carbonic anhydrase inhibitor acetazolamide The technical experience obtained in this study will be used to design a study of the pharmacological and physiological mechanisms underlying cerebral blood flow increases during hypercapnia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-CC-0164 | None | None | None |