Ignite Creation Date:
2025-12-24 @ 9:19 PM
Ignite Modification Date:
2025-12-25 @ 7:07 PM
Study NCT ID:
NCT03373604
Status:
COMPLETED
Last Update Posted:
2025-05-08
First Post:
2017-12-11
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Imaging Tau in Alzheimer's Disease and Normal Aging
Sponsor:
Patrick Lao
Organization:
Study Overview
Official Title:
Imaging Tau in Alzheimer's Disease and Normal Aging With 18F-MK-6240
Status:
COMPLETED
Status Verified Date:
2025-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is being done to learn about tau tangles in Alzheimer's disease. A type of positron emission tomography (PET) scan is used to measure the abnormal accumulation of protein called tau in the brain. These are thought to be involved in Alzheimer's disease. The investigators will also perform brain MRI and to tests to measure the participant's memory and thinking.
Detailed Description:
This study is being done to determine the relationship between tau tangles and cognitive impairment in elderly subjects with and without Alzheimer's disease (AD). Subjects will undergo screen that includes neuropsychological testing and brain MRI. This study uses a special type of scan called a PET scan to take pictures of the brain. During the PET scan, a special radioactive dye called 18F-MK-6240 is injected into the body. 18F-MK-6240 sticks to abnormal tangles made of the protein tau. Subjects will have the option to have lumbar puncture performed to measure CSF concentrations of biomarkers.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| K23AG052633-02 | NIH | None | https://reporter.nih.gov/quic… | View |
| 2R56AG034189-06A1 | NIH | None | https://reporter.nih.gov/quic… | View |
| K24AG045334 | NIH | None | https://reporter.nih.gov/quic… | View |
| R01AG055299 | NIH | None | https://reporter.nih.gov/quic… | View |
| R01AG050440-02S1 | NIH | None | https://reporter.nih.gov/quic… | View |