Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005502
Status:
COMPLETED
Last Update Posted:
2013-05-14
First Post:
2000-05-25
Brief Title:
Coronary Disease Morbidity and Mortality in a Population
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Coronary Disease Morbidity and Mortality in a Population
Status:
COMPLETED
Status Verified Date:
2013-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the entire population of Olmsted County Minnesota including all age categories to examine the secular trends in coronary heart disease CHD mortality myocardial infarction MI incidence and natural history including MI severity case fatality and post-MI morbidity Also to examine the time trends in the prevalence of CHD at post-mortem because of the uniquely high autopsy rate in Olmsted County
Detailed Description:
BACKGROUND
Cardiovascular disease remains the leading cause of death in the US Despite an encouraging decline in age-adjusted coronary heart disease CHD mortality prevalent CHD continues to represent a major health burden particularly in the elderly population Most community surveillance programs however cannot fully characterize this problem because they are restricted to an upper age limit of 74 years and thus do not include the events occurring in an increasingly growing part of the population Observational studies have questioned the existence of a change over time in the prevalence of anatomic coronary disease either at post-mortem examination or at coronary angiography This remains to be further examined in a population-based setting In addition the natural history of myocardial infarction MI in the reperfusion area is unknown in particular there are no population-based data on the incidence of post-MI heart failure
DESIGN NARRATIVE
The records of all Olmsted County residents with a hospital discharge diagnosis of MI between 1979 and 1999 were reviewed and standard epidemiologic MI validation criteria were applied post-MI outcome over time was determined including post-MI heart failure angina 30 day case fatality and long-term survival In parallel with the analysis of time trends in CHD mortality the autopsy reports were reviewed to examine whether the prevalence of coronary disease at autopsy has changed over time These studies provided an assessment of the clinical and anatomical manifestations of CHD including the outcome of acute MI over a time period characterized by intensified primary prevention efforts and major changes in the treatment of acute CHD
The study was renewed in July 2002 to continue surveillance of acute coronary heart disease events in order to address issues surrounding the diagnostic precision and risk stratification potential of troponin and high sensitivity C reactive protein CRP and to monitor secular trends in severity and treatment modalities Novel approaches to the procurement of carefully timed blood samples allow direct measurement of the increase in number of cases of myocardial infarction using the new biomarker troponin An examination will be made of the prognostic value of quantitative peak troponin measured at 24 to 36 hours and high sensitivity C reactive protein measured early after symptom onset in the myocardial infarction cohort
Cardiovascular disease remains the leading cause of death in the US Despite an encouraging decline in age-adjusted coronary heart disease CHD mortality prevalent CHD continues to represent a major health burden particularly in the elderly population Most community surveillance programs however cannot fully characterize this problem because they are restricted to an upper age limit of 74 years and thus do not include the events occurring in an increasingly growing part of the population Observational studies have questioned the existence of a change over time in the prevalence of anatomic coronary disease either at post-mortem examination or at coronary angiography This remains to be further examined in a population-based setting In addition the natural history of myocardial infarction MI in the reperfusion area is unknown in particular there are no population-based data on the incidence of post-MI heart failure
DESIGN NARRATIVE
The records of all Olmsted County residents with a hospital discharge diagnosis of MI between 1979 and 1999 were reviewed and standard epidemiologic MI validation criteria were applied post-MI outcome over time was determined including post-MI heart failure angina 30 day case fatality and long-term survival In parallel with the analysis of time trends in CHD mortality the autopsy reports were reviewed to examine whether the prevalence of coronary disease at autopsy has changed over time These studies provided an assessment of the clinical and anatomical manifestations of CHD including the outcome of acute MI over a time period characterized by intensified primary prevention efforts and major changes in the treatment of acute CHD
The study was renewed in July 2002 to continue surveillance of acute coronary heart disease events in order to address issues surrounding the diagnostic precision and risk stratification potential of troponin and high sensitivity C reactive protein CRP and to monitor secular trends in severity and treatment modalities Novel approaches to the procurement of carefully timed blood samples allow direct measurement of the increase in number of cases of myocardial infarction using the new biomarker troponin An examination will be made of the prognostic value of quantitative peak troponin measured at 24 to 36 hours and high sensitivity C reactive protein measured early after symptom onset in the myocardial infarction cohort
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL059205 | NIH | None | httpsreporternihgovquickSearchR01HL059205 |