Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004305
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2002-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Determine whether allelic differences associated with the fourth component of complement type-1 complement receptor expressed on erythrocytes and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis IgA-N
II Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls
II Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls
Detailed Description:
PROTOCOL OUTLINE
Participants undergo qualitative genetic analysis of complement-related proteins Studies include genomic re-arrangement of 4-gene unit C4 DNA sequence and RNA expression type-1 complement receptor DNA sequence Fc-gamma receptor IIIA isoform analysis classical and alternative complement activation pathway assays plasma C4 and C4d protein levels and immunoglobulin patterns in glomerular deposits
Participants undergo qualitative genetic analysis of complement-related proteins Studies include genomic re-arrangement of 4-gene unit C4 DNA sequence and RNA expression type-1 complement receptor DNA sequence Fc-gamma receptor IIIA isoform analysis classical and alternative complement activation pathway assays plasma C4 and C4d protein levels and immunoglobulin patterns in glomerular deposits
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OSU-94H0338 | None | None | None |