Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001260
Status:
TERMINATED
Last Update Posted:
2019-12-09
First Post:
1999-11-03
Brief Title:
Brain Tissue Collection for Neuropathological Studies
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Brain Procurement for the Human Brain Collection Core
Status:
TERMINATED
Status Verified Date:
2017-06-16
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders
This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders We do not accept prospective donations
This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders We do not accept prospective donations
Detailed Description:
The knowledge of how affected tissue deviates from normal control tissue is an integral part of fully understanding a neurological or psychiatric disorder The purpose of this protocol is to establish a coordinating program with the Office of the Chief Medical Examiner in Washington DC the Virginia Office of the Chief Medical Examiner Central District and Virginia the Office of the Chief Medical Examiner Northern District for the donation of brain tissue
Dissected brain tissue from selected brain regions including but not limited to the dorsolateral prefrontal cortex and hippocampal formation will be assembled from large cohorts of normal controls and schizophrenic subjects The expression of mRNA and protein for selected molecules chosen on the basis of their genetic association with schizophrenia will be measured with a variety of assays including but not limited to qPCR and Western blots
Outcome measures are the statistical comparison within normal controls of mRNA andor protein levels in groups segmented by genotype Similar comparisons will be made between schizophrenic cohorts and normal controls in a diagnosis by genotype analysis with an ANOVA or when appropriate an ANCOVA controlling for variables such as age race gender and postmortem interval
Dissected brain tissue from selected brain regions including but not limited to the dorsolateral prefrontal cortex and hippocampal formation will be assembled from large cohorts of normal controls and schizophrenic subjects The expression of mRNA and protein for selected molecules chosen on the basis of their genetic association with schizophrenia will be measured with a variety of assays including but not limited to qPCR and Western blots
Outcome measures are the statistical comparison within normal controls of mRNA andor protein levels in groups segmented by genotype Similar comparisons will be made between schizophrenic cohorts and normal controls in a diagnosis by genotype analysis with an ANOVA or when appropriate an ANCOVA controlling for variables such as age race gender and postmortem interval
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 90-M-0142 | None | None | None |