Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00017875
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-06-15
Brief Title:
Transcranial Magnetic Stimulation TMS Studies of Dystonia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Neurophysiological Studies of Focal and Generalized Forms of Dystonia Using Transcranial Magnetic Stimulation TMS
Status:
COMPLETED
Status Verified Date:
2005-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation to examine how the brain controls muscle movement in focal and generalized types of dystonia Dystonia is a movement disorder in which involuntary muscle contractions cause uncontrolled twisting or abnormal postures Dystonia may be focal involving just one region of the body such as the hand neck or face Focal dystonia usually begins in adulthood Generalized dystonia on the other hand generally begins in childhood or adolescence Symptoms begin in one area and then become more widespread
Healthy normal volunteers and patients with focal or generalized dystonia 8 years of age and older may be eligible for this study First-degree relatives of patients will also be enrolled
In transcranial magnetic stimulation an insulated wire coil is placed on the subjects scalp and brief electrical currents are passed through the coil creating magnetic pulses that pass into the brain These pulses generate very small electrical currents in the cortex-the outer part of the brain-briefly disrupting the function of the brain cells in the stimulated area The stimulation may cause muscle twitching or tingling in the scalp face and limbs During the stimulation the subject will be asked to either keep the hand relaxed or to slightly tense certain muscles in the hand or arm The test will last about 15 hours
The cause of dystonia is unknown It is hoped that a comparison of brain activity in normal volunteers patients and their relatives not affected by dystonia will help scientists learn why some people develop dystonic movements
Healthy normal volunteers and patients with focal or generalized dystonia 8 years of age and older may be eligible for this study First-degree relatives of patients will also be enrolled
In transcranial magnetic stimulation an insulated wire coil is placed on the subjects scalp and brief electrical currents are passed through the coil creating magnetic pulses that pass into the brain These pulses generate very small electrical currents in the cortex-the outer part of the brain-briefly disrupting the function of the brain cells in the stimulated area The stimulation may cause muscle twitching or tingling in the scalp face and limbs During the stimulation the subject will be asked to either keep the hand relaxed or to slightly tense certain muscles in the hand or arm The test will last about 15 hours
The cause of dystonia is unknown It is hoped that a comparison of brain activity in normal volunteers patients and their relatives not affected by dystonia will help scientists learn why some people develop dystonic movements
Detailed Description:
The objective of this study is to evaluate intracortical inhibition ICI in focal dystonia and in generalized dystonia of known genetic origin DYT1 dystonia in order to determine whether abnormalities of ICI can represent a marker of genetic predisposition for the development of dystonia It is unclear why some carriers of the DYT1 dystonia do not develop dystonic symptoms One possible explanation is that the development of dystonia is a two-stage process first loss of ICI which may be genetically determined and second exposure to an environmental trigger such as excessive repetitive movements Thus we hypothesize that impaired ICI may serve as a marker for the DYT1 carrier state There is good evidence that focal dystonia is a genetically determined disorder but the gene responsible remains undetermined We hypothesize that in up to 50 of first degree relatives of patients with focal dystonia impaired ICI may be found which would serve as a gene marker for the abnormality In those individuals with this genetic marker of impaired ICI further linkage analysis studies could be performed to identify the causative gene In this study we propose to measure ICI using transcranial magnetic stimulation in patients with both focal and generalized forms of dystonia their first degree relatives and an age matched control group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-N-0188 | None | None | None |