Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00013715
Status:
COMPLETED
Last Update Posted:
2008-08-11
First Post:
2001-03-28
Brief Title:
Ozone and Rhinovirus-Induced Disease in Asthmatics
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the US morbidity associated with human rhinovirus RV infection represents a major health problem In asthmatics up to 80 of asthma exacerbations are associated with upper respiratory infections Despite evidence that environmental oxidant pollutants such as ozone may increase the severity of viral disease the mechanisms underlying such an effect have not been identified This study will test the hypothesis that exposure of allergic asthmatic subjects to ambient levels of ozone directly enhances viral disease by increasing infectivity and intensifying virus-induced inflammation
Detailed Description:
In mild asthmatics the study will investigate 1 if exposure to ozone will enhance the viral infective process in the nasal epithelium 2 the effect of ozone exposure on RV-induced inflammatory gene expression mediator release and inflammatory cell influx into the upper and lower airways and 3 the interactive effects of ozone and RV on airway reactivity This information will improve our understanding of the risk associated with oxidant pollutant exposure in this population of individuals in whom RV infection may represent a significant health concern
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None