Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00015483
Status:
COMPLETED
Last Update Posted:
2006-09-04
First Post:
2001-04-20
Brief Title:
Hematotoxic Effects of Particulate Exposure
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
Hematotoxic Effects of Benzene and Doxorubicin
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hematotoxicity is caused by a number of agents such as a benzene by-product called hydroquinone and the antitumor agent doxorubicin This is a basic research study conducted using normal human donors of mechanisms involved in hematotoxicity and of the protective response of human hematopoietic progenitor cells to hematotoxic agents Tumor necrosis factor exposure protects these cells from a subsequent exposure to hematotoxic agents The alteration of gene expression in these cells caused by tumor necrosis factor is being studied Additionally the tumor necrosis factor-induced biochemical pathways involved in protection of human hematopoietic progenitor cells will be studied
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None