Ignite Creation Date:
2025-12-24 @ 10:03 PM
Ignite Modification Date:
2025-12-25 @ 7:39 PM
Study NCT ID:
NCT02807935
Status:
UNKNOWN
Last Update Posted:
2016-06-23
First Post:
2016-06-17
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The in Vivo Effect of Medical and Surgical Glaucoma Treatments on the Schlemm's Canal Micro-structure
Sponsor:
Sheba Medical Center
Organization:
Study Overview
Official Title:
The in Vivo Effect of Medical and Surgical Glaucoma Treatments on the Schlemm's Canal
Status:
UNKNOWN
Status Verified Date:
2016-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of our current series of studies is to evaluate different glaucoma treatments in vivo effect on the conventional outflow pathway, and specifically on the Schlemm's canal (SC) anatomy using Enhanced Depth Imaging (EDI)-optical coherence tomography (OCT) . The images will be taken as part of the patients routine medical follow up (before starting the treatment, and 1,4 and 12 weeks afterwards) diameter, cross-sectional area and volume will be measured using commercially available 3-dimensional reconstruction.
The series of studies will be divided into 3 branches, each branch contains different treatments.For each treatment different patients will be recruited.
The branches are as following-
1. The surgical branch-
1. Before and after trabeculotomy
2. Before and after cataract surgery
3. Before and after vitrectomy surgery
4. Before and after XEN™ Gel Stent implant
2. The pharmacological branch-
1. Before and during the treatment with prostaglandins analogs
2. Before and during the treatment with alpha blockers
3. Before and during the treatment with beta blockers
4. Before and during the treatment with carbonic anhydrase inhibitor
3. The laser branch-
1. Before and after trabeculoplasty
2. Before and after laser iridotomy
3. Before and after yag capsulotomy laser
The series of studies will be divided into 3 branches, each branch contains different treatments.For each treatment different patients will be recruited.
The branches are as following-
1. The surgical branch-
1. Before and after trabeculotomy
2. Before and after cataract surgery
3. Before and after vitrectomy surgery
4. Before and after XEN™ Gel Stent implant
2. The pharmacological branch-
1. Before and during the treatment with prostaglandins analogs
2. Before and during the treatment with alpha blockers
3. Before and during the treatment with beta blockers
4. Before and during the treatment with carbonic anhydrase inhibitor
3. The laser branch-
1. Before and after trabeculoplasty
2. Before and after laser iridotomy
3. Before and after yag capsulotomy laser
Detailed Description:
None
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: