Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00018720
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2001-07-03
Brief Title:
Regulation of Sterol Homeostasis
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Regulation of Sterol Homeostasis
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids compounds made in the body from cholesterol
This project has two objectives A To define the mechanism of impaired bile acid absorption in hypertriglyceridemia specifically we will determine if the active or passive component of absorption is abnormal and B to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol Because 27-hydroxylase is present in endothelial cells as well as liver this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque
This project has two objectives A To define the mechanism of impaired bile acid absorption in hypertriglyceridemia specifically we will determine if the active or passive component of absorption is abnormal and B to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol Because 27-hydroxylase is present in endothelial cells as well as liver this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None