Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00018239
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2001-07-03
Brief Title:
Aging and Cellular Mechanism for Insulin Action After Exercise Training
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Aging and Cellular Mechanism for Insulin Action After Exercise Training
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine whether the metabolic and cellular mechanisms contributing to improved insulin action after aerobic or resistive exercise are different in older obese insulin resistant veterans The hypothesis is that regular exercise whether aerobic or resistive will improve whole body insulin action but the nature and magnitude of changes in skeletal muscle will differ between the two types of exercise
Detailed Description:
Veterans will be of comparable body composition and age and randomly assigned to either aerobic or resistive exercise They will be instructed in a weight maintenance diet prior to beginning the exercise program and maintain this diet throughout the study Metabolic testing will be performed at baseline and after 6 months of exercise training Testing will include measurement of body composition anthropometry dual-energy Xray absorptiometry computed tomograph scan maximal oxygen consumption and muscle strength glucose tolerance oral glucose tolerance test insulin sensitivity euglycemic-hyperinsulinemic clamp and muscle biopsies to examine skeletal muscle metabolic characteristics fiber type distribution capillary density oxidative and glycolytic enzyme activities and levels of key proteins important in insulin signaling and glucose transport Data will be analyzed using analysis of variance to determine differences between the two exercise groups and multiple regression analysis to determine the primary adaptations that are associated with the improvements in whole body insulin action
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None