Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00018330
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2001-07-03
Brief Title:
Genetics Metabolism and Weight Loss in Older Obese Veterans
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Genetics Metabolism and Weight Loss in Older Obese Veterans
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to determine whether sequence variation in the lipoprotein lipase LPQ gene affects the amount of weight loss and metabolic responses during a hypocaloric diet treatment for overweight and obese BMI25-35 kgm2 older 50-65 yrs sedentary veterans
Detailed Description:
Veterans who are 50-65 yrs non-smoking sedentary and weight stable with a BMI between 25-35 kgm2 120-150 desirable body weight are recruited and screened via telephone medical history and physical exam Exclusion criteria are diabetes hypertriglyceridemia 400 mgdl history of cancer or myocardial infarction clinical depression renal liver or hematologic disease and medications that affect glucose or lipid metabolism thiazides estrogen replacement beta-blockers Changes in total and visceral body fat are measured by dual x-ray absorptiometry and computerized tomography resting energy expenditure and fat oxidation rate by indirect calorimetry and lipoprotein lipids by enzymatic assay Glucose tolerance is assessed during a three-hour oral glucose tolerance test with measurement of glucose- and insulin levels every 30 minutes LPL activity is measured in 3050mg pieces of subcutaneous abdominal and gluteal adipose tissue
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None