Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00029068
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-01-04
Brief Title:
Cortical Excitability in Obsessive-Compulsive and Related Disorders
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Studies of Cortical Excitability in Obsessive-Compulsive Disorder Related Disorder and Healthy Volunteers Using Paired-Pulse Transcranial Magnetic Stimulation
Status:
COMPLETED
Status Verified Date:
2003-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation TMS to study the function of the cerebral cortex outer layer of the brain in people with obsessive compulsive disorder OCD and related disorders A non-invasive procedure TMS activates areas of the brain with magnetic pulses that travel through the scalp and head and cause small electrical currents in the brain
People 18 years of age and older with OCD and disorders that may be related-tic disorders such as Tourettes syndrome focal dystonia localized muscle cramps body dysmorphic disorder hypersensitivity to changes in appearance eating disorders such as anorexia nervosa trichotillomania compulsive hair-pulling-may be eligible for this study Healthy normal volunteers will also be enrolled Candidates will be screened by telephone interview
Participants will undergo TMS For this procedure an insulated wire coil is placed on the subjects head A brief electrical current passes through the coil creating a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain The stimulation may cause muscle hand or arm twitching or may affect movement or reflexes During the stimulation the subject may be asked to tense certain muscles slightly or perform other simple actions The electrical activity of muscles during stimulation is recorded with a computer or other recording device using electrodes attached to the skin with tape
Subjects will receive fewer than 500 magnetic pulses and the study will take less than 3 hours Participants may repeat the procedure on several occasions if they agree
People 18 years of age and older with OCD and disorders that may be related-tic disorders such as Tourettes syndrome focal dystonia localized muscle cramps body dysmorphic disorder hypersensitivity to changes in appearance eating disorders such as anorexia nervosa trichotillomania compulsive hair-pulling-may be eligible for this study Healthy normal volunteers will also be enrolled Candidates will be screened by telephone interview
Participants will undergo TMS For this procedure an insulated wire coil is placed on the subjects head A brief electrical current passes through the coil creating a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain The stimulation may cause muscle hand or arm twitching or may affect movement or reflexes During the stimulation the subject may be asked to tense certain muscles slightly or perform other simple actions The electrical activity of muscles during stimulation is recorded with a computer or other recording device using electrodes attached to the skin with tape
Subjects will receive fewer than 500 magnetic pulses and the study will take less than 3 hours Participants may repeat the procedure on several occasions if they agree
Detailed Description:
Transcranial magnetic stimulation TMS a noninvasive means of stimulating the brain through the scalp and skull has become an important tool in neurophysiology and neuropsychiatry The purpose of this project is 1 to use TMS as a probe of cortical excitability to investigate the physiology of the cerebral cortex in Obsessive-Compulsive Disorder OCD and OCD-related disorders including the OCD spectrum which we believe to be disorders involving alterations in the excitability of the cortex 2 to compare those findings to results in healthy individuals and 3 to evaluate the possible effects of various pharmacological treatments on TMS parameters in individuals with OCD and OCD-related disorders This protocol seeks to evaluate the hypothesis that TMS may provide a sensitive measure of cortical function that is relevant to the underlying pathology in OCD and OCD-related disorders The identification of possible anomalies of TMS measures in these patient groups and changes elicited by pharmaceutical agents will be useful in orienting research towards investigations of the cortical neurotransmitter systems
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-M-0076 | None | None | None |