Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00024596
Status:
COMPLETED
Last Update Posted:
2015-12-22
First Post:
2001-09-21
Brief Title:
Family Heart Study - Subclinical Atherosclerosis Network FHS-SCAN
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2015-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine familial and non-familial causes for susceptibility to atherosclerosis and the inflammatory response
Detailed Description:
BACKGROUND
Atherosclerotic cardiovascular disease along with its related health expenditures mortality and morbidity remains among the most significant health-related conditions in the United States and other developed countries The substantial resources that have been expended to investigate this problem have led to significant scientific advances in the basic biology clinical management epidemiology and public health intervention approaches Despite these real advances there remains much more to be done in terms of understanding the basic biological and social processes treatment and public health programs
Just as earlier research was effective in identifying a variety of epidemiologic risk factors for cardiovascular disease recent advances make it possible to bring to bear a variety of new and powerful tools to detailed study of the basic processes involved in atherogenesis Application of these tools in combination with synthesis of prior basic and epidemiologic results provides a powerful approach that is more model-driven than many previous studies
DESIGN NARRATIVE
The Subclinical Atherosclerosis Network is a multicenter study of the genetic epidemiology of coronary and aortic calcification and of inflammatory markers It examines two areas of great interest in contemporary vascular medicine namely vascular calcification and inflammation in approximately 3000 persons who have been recruited to the Family Heart Study with additional persons of African American descent contributed by the HyperGEN Study Considerable data including a large number of genotypes have been collected in the Family Heart Study The subjects will be brought back for additional data collection including the measurement of inflammatory markers and coronary and aortic calcification by computed tomography CT
The network will quantify coronary and aortic artery calcium volume in 441 selected informative pedigrees approximately 3000 individuals previously examined and extensively genotyped approximately 400 markers spanning the genome by the NHLBI Family Heart Study in order to identify genes associated with human atherosclerosis An additional 275 African American sibships approximately 600 individuals also examined and comparably genotyped will be included to address these study questions in this high-risk population Assessment of the inter-individual variability in the inflammatory burden and the host response and the extensive metabolic behavioral and environmental data already collected on these pedigrees will provide enhanced phenotypic homogeneity and increased analytic power in assessing the genetic basis of atherosclerosis
State of the art laboratory and statistical methods will be used to find localize and characterize the influence of predisposing genes to atherosclerosis and the inflammatory response Novel genetic analysis methods will be used to address the issues of phenotypic genetic and population heterogeneity epistasis complex interactions among the genetic and environmental risk factors and to optimize the detection of genomic regions affecting phenotypic susceptibility
Atherosclerotic cardiovascular disease along with its related health expenditures mortality and morbidity remains among the most significant health-related conditions in the United States and other developed countries The substantial resources that have been expended to investigate this problem have led to significant scientific advances in the basic biology clinical management epidemiology and public health intervention approaches Despite these real advances there remains much more to be done in terms of understanding the basic biological and social processes treatment and public health programs
Just as earlier research was effective in identifying a variety of epidemiologic risk factors for cardiovascular disease recent advances make it possible to bring to bear a variety of new and powerful tools to detailed study of the basic processes involved in atherogenesis Application of these tools in combination with synthesis of prior basic and epidemiologic results provides a powerful approach that is more model-driven than many previous studies
DESIGN NARRATIVE
The Subclinical Atherosclerosis Network is a multicenter study of the genetic epidemiology of coronary and aortic calcification and of inflammatory markers It examines two areas of great interest in contemporary vascular medicine namely vascular calcification and inflammation in approximately 3000 persons who have been recruited to the Family Heart Study with additional persons of African American descent contributed by the HyperGEN Study Considerable data including a large number of genotypes have been collected in the Family Heart Study The subjects will be brought back for additional data collection including the measurement of inflammatory markers and coronary and aortic calcification by computed tomography CT
The network will quantify coronary and aortic artery calcium volume in 441 selected informative pedigrees approximately 3000 individuals previously examined and extensively genotyped approximately 400 markers spanning the genome by the NHLBI Family Heart Study in order to identify genes associated with human atherosclerosis An additional 275 African American sibships approximately 600 individuals also examined and comparably genotyped will be included to address these study questions in this high-risk population Assessment of the inter-individual variability in the inflammatory burden and the host response and the extensive metabolic behavioral and environmental data already collected on these pedigrees will provide enhanced phenotypic homogeneity and increased analytic power in assessing the genetic basis of atherosclerosis
State of the art laboratory and statistical methods will be used to find localize and characterize the influence of predisposing genes to atherosclerosis and the inflammatory response Novel genetic analysis methods will be used to address the issues of phenotypic genetic and population heterogeneity epistasis complex interactions among the genetic and environmental risk factors and to optimize the detection of genomic regions affecting phenotypic susceptibility
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL088215 | NIH | None | httpsreporternihgovquickSearchR01HL088215 |