Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00025701
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2001-10-11
Brief Title:
EEG and EMG Studies of Hand Dystonia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
EEG Study of Movement-Related Center-Surround Organization in Hand Dystonia
Status:
COMPLETED
Status Verified Date:
2010-10-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease It will use electroencephalography EEG and electromyography EMG to compare brain function in normal subjects and in patients with focal hand dystonia In dystonia involuntary muscle movements or spasms cause uncontrolled twisting and repetitive movement or abnormal postures Focal dystonia involves just one region of the body such as the hand neck or face
EEG measures the electrical activity of the brain The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head EMG measures electrical activity from muscles It uses wire electrodes placed on the skin over the muscles
Adult healthy normal volunteers and patients with focal hand dystonia may be eligible for this study Patients will be selected from NINDSs dystonia patient database
Participants will sit in a semi-reclining chair in a darkened room and be asked to move either their right index finger right foot or the angle of their mouth on the right side at a rate of one movement every 10 seconds Brain and muscle activity will be measured during this task with EEG and EMG recordings
EEG measures the electrical activity of the brain The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head EMG measures electrical activity from muscles It uses wire electrodes placed on the skin over the muscles
Adult healthy normal volunteers and patients with focal hand dystonia may be eligible for this study Patients will be selected from NINDSs dystonia patient database
Participants will sit in a semi-reclining chair in a darkened room and be asked to move either their right index finger right foot or the angle of their mouth on the right side at a rate of one movement every 10 seconds Brain and muscle activity will be measured during this task with EEG and EMG recordings
Detailed Description:
Objective
To find and quantify EEGMEG correlates of cortical center-surround organization and intracortical inhibition
To compare these between healthy volunteers and focal hand dystonia FHD patients
Study Population
- Healthy volunteers and FHD patients
Design
- The study has two separate arms aiming to examine the same question In the first one subjects perform a 4-choice contingence negative variation CNT type motor task while multi-channel EEG and EMG are recorded In the second arm somatosensory evoked potentials SEPs or fields SEFs are recorded to median nerve stimulation
Outcome Measures
- First arm EEG band-power difference between center and surround Second arm number amplitude and power of high frequency oscillations HFOs component of SEPsSEFs
To find and quantify EEGMEG correlates of cortical center-surround organization and intracortical inhibition
To compare these between healthy volunteers and focal hand dystonia FHD patients
Study Population
- Healthy volunteers and FHD patients
Design
- The study has two separate arms aiming to examine the same question In the first one subjects perform a 4-choice contingence negative variation CNT type motor task while multi-channel EEG and EMG are recorded In the second arm somatosensory evoked potentials SEPs or fields SEFs are recorded to median nerve stimulation
Outcome Measures
- First arm EEG band-power difference between center and surround Second arm number amplitude and power of high frequency oscillations HFOs component of SEPsSEFs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0010 | None | None | None |