Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00023114
Status:
COMPLETED
Last Update Posted:
2006-09-04
First Post:
2001-08-22
Brief Title:
p450 Mediated Lung Toxicity
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity All of the toxicants in question are encountered by humans in the workplace through lifestyle choices cigarette smoking and as a result of environmental contamination The high incidence of pulmonary diseases in the human population means that it will be difficult if not impossible to determine whether humans are at risk from exposure to these chemicals without solid mechanistic data Recent rodent bioassays suggest that these compounds have oncogenic potential further supporting the need to test the potential for injury in primates As part of this testing we intend to establish in vitro methods for assessing critical steps in the metabolism of these agents and their interaction with cellular macromolecules Once this is done similar studies can be conducted in Rhesus or in human lung tissue that is available because it cannot be used for transplant purposes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None