Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00024999
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-10-10
Brief Title:
EEG and EMG Analysis of Ideomotor Apraxia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
EEG Analysis of Ideomotor Apraxia
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease It will use electroencephalography EEG and electromyography EMG to compare brain function in normal subjects and in patients with-a disorder affecting patients with stroke and other brain lesions These patients have problems with timing sequence and spatial organization of certain types of movements
EEG measures the electrical activity of the brain The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head EMG measures electrical activity from muscles It uses wire electrodes placed on the skin over the muscles
Adult healthy normal volunteers and patients with ideomotor apraxia with a single left brain lesion may be eligible for this study
Study participants will be asked to make certain movements with their arms or hands such as waving and using scissors Brain and muscle activity will be measured during these tasks with EEG and EMG recordings Patients may be asked to repeat these tests over time as their condition changes such as during recovery from a stroke to gain information about the recovery process
EEG measures the electrical activity of the brain The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head EMG measures electrical activity from muscles It uses wire electrodes placed on the skin over the muscles
Adult healthy normal volunteers and patients with ideomotor apraxia with a single left brain lesion may be eligible for this study
Study participants will be asked to make certain movements with their arms or hands such as waving and using scissors Brain and muscle activity will be measured during these tasks with EEG and EMG recordings Patients may be asked to repeat these tests over time as their condition changes such as during recovery from a stroke to gain information about the recovery process
Detailed Description:
Ideomotor apraxia is a disorder affecting patients with stroke and a variety of other brain lesions The disorder involves problematic timing sequence and spatial organization of gestured movements As a result patients suffer from incorrect temporal and spatial components to movements as evidenced during pantomime of transitive and intransitive movements The errors can be seen in left and right hemisphere damaged patients during intransitive movements but lesions predominate in the left hemisphere for inability to pantomime transitive movements Thus far damage to parietofrontal circuits has been implicated in significantly contributing to this disorder These circuits which pave the way for sensorimotor processing are of clear interest in the nature of praxis
In the present study we plan to evaluate further the parietofrontal circuits in these patients Using EEG we will analyze the movement related cortical potentials MRCP in these patients compared to controls to evaluate any cortical planning differences We will analyze how the circuits play a role in transitive and intransitive movements in normal subjects and patients with Ideomotor apraxia Each patient will make a series of movement during 64 channel EEG and EMG recordings Following recordings analysis will be made of the event related desynchronization ERD and the MRCP Further analysis will look at the activation of the parietofrontal circuitry in patients using correlation and coherence methods For the same purposes MEG studies will be performed to assess similar measures
In the present study we plan to evaluate further the parietofrontal circuits in these patients Using EEG we will analyze the movement related cortical potentials MRCP in these patients compared to controls to evaluate any cortical planning differences We will analyze how the circuits play a role in transitive and intransitive movements in normal subjects and patients with Ideomotor apraxia Each patient will make a series of movement during 64 channel EEG and EMG recordings Following recordings analysis will be made of the event related desynchronization ERD and the MRCP Further analysis will look at the activation of the parietofrontal circuitry in patients using correlation and coherence methods For the same purposes MEG studies will be performed to assess similar measures
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0011 | None | None | None |