Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00025844
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2001-10-26
Brief Title:
Fear Conditioning Using Computer-Generated Virtual Reality
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Fear Conditioning Using Computer-Generated Virtual Reality
Status:
COMPLETED
Status Verified Date:
2012-04-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to use a computer-generated virtual reality environment to study fear conditioning Fear conditioning is used to explore the causes and persistence of anxiety and anxiety disorders
When confronted with fearful or unpleasant events people can develop fear of specific cues that were associated with these events as well as to the environmental context in which the events occurred via a process called classical or aversive conditioning Advances in computer-generated visual stimulations could facilitate the design of new aversive conditioning studies This study will develop a virtual reality environment to examine human contextual fear conditioning in the laboratory During the procedure moderately painful stimuli will be administered Participants in this study will be screened with a medical history physical examination psychiatric evaluation and hearing test Participants will wear headphones and special goggles that will enable them to view a virtual reality environment Measures will be taken during the study to see how the brain adapts to environmental stimuli
When confronted with fearful or unpleasant events people can develop fear of specific cues that were associated with these events as well as to the environmental context in which the events occurred via a process called classical or aversive conditioning Advances in computer-generated visual stimulations could facilitate the design of new aversive conditioning studies This study will develop a virtual reality environment to examine human contextual fear conditioning in the laboratory During the procedure moderately painful stimuli will be administered Participants in this study will be screened with a medical history physical examination psychiatric evaluation and hearing test Participants will wear headphones and special goggles that will enable them to view a virtual reality environment Measures will be taken during the study to see how the brain adapts to environmental stimuli
Detailed Description:
Fear conditioning paradigms are tools to explore symptoms of anxiety disorders During fear conditioning the organism develops fear to the phasic explicit cue eg a light that was associated with the aversive unconditioned stimulus eg a shock during conditioning as well as to the environmental context eg the experimental room Explicit cue conditioning and context conditioning are separate processes mediated by distinct brain structures Whereas explicit cue conditioning is only dependent on the amygdala context conditioning involves the amygdala the hippocampus and the bed nucleus of the stria terminalis BNST We have been using explicit cue and context conditioning as models of phasic fear and sustained anxiety respectively However contextual fear is relatively difficult to study in humans in the laboratory because it requires two experimental sessions and the use of different experimental rooms Advances in computer-generated visual stimulation now offer the possibility to develop more sophisticated paradigms in the laboratory that could facilitate the design of fear conditioning studies In addition compared to traditional paradigms computer generated three-dimensional stimulation provides the opportunity to create more realistic virtual environment The main objective of this study is to use virtual reality to further our understanding of fear conditioning in humans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-M-0003 | None | None | None |