Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00026598
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-11-10
Brief Title:
Effect of Stimulus Rate on Cognitive and Motor Activity in Young Subjects Elderly Subjects and Patients With Parkinsons Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Effect of Stimulus Rate on Cognitive and Motor Activity in Young Subjects Elderly Subjects and Patients With Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2003-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate how changes in the brain associated with Parkinsons disease influence the control of motor and thinking speed There is disagreement over whether patients with Parkinsons disease are slow in thinking as well as movement This study may provide a new framework to explain the relationship between motor and cognitive aspects of human behavior and help to clarify the pathophysiology of Parkinsons disease
There are two parts to the study behavioral tests and functional magnetic resonance imaging fMRI All participants will be asked about their medical history have a physical examination and complete a questionnaire They must not take regular medications including levodopa and dopamine agonists for 8 hours prior to the study
The behavioral study involves computer-generated neuropsychological tasks including hand movements imagination of movements and mental calculations Response will be recorded and evaluated Electrodes may be placed on the participants skin to measure surface electromyogram EMG
The fMRI study involves MRI scanning in which motor and thinking tasks are performed Electrodes may be placed on the skin to monitor muscle activity
Thirty patients ages 40 and up with early-stage Parkinsons disease will be recruited Sixty normal volunteers ages 21-75 will be included as well for comparison
There are two parts to the study behavioral tests and functional magnetic resonance imaging fMRI All participants will be asked about their medical history have a physical examination and complete a questionnaire They must not take regular medications including levodopa and dopamine agonists for 8 hours prior to the study
The behavioral study involves computer-generated neuropsychological tasks including hand movements imagination of movements and mental calculations Response will be recorded and evaluated Electrodes may be placed on the participants skin to measure surface electromyogram EMG
The fMRI study involves MRI scanning in which motor and thinking tasks are performed Electrodes may be placed on the skin to monitor muscle activity
Thirty patients ages 40 and up with early-stage Parkinsons disease will be recruited Sixty normal volunteers ages 21-75 will be included as well for comparison
Detailed Description:
A high-level of motor control often requires complex processing of sensory information Such a cognitive aspect of motor control is supposed to share underlying neural components with non-motor cognitive operations The present study is aimed to clarify the similarity and difference between cognitive processing for motor control and non-motor cognitive processing especially in terms of the speed of processing From this standpoint patients with Parkinsons disease who manifest motor slowing as well as possible cognitive slowing will provide an interesting model to explore similar control mechanisms of speed for motor and non-motor behavioral control Using psychophysical observations we will try to clarify normal and diseased control of motor and cognitive speed Furthermore using functional magnetic resonance imaging fMRI we will explore the neural correlates underlying control of motor and cognitive speed in normal brains as well as pathologic brains Blood-oxygen-level-dependent signal changes measured by fMRI as an index of the activity of a neural population are expected to reveal underactivity or compensatory overactivity in the functionally impaired brain areas responsible for slowing of movement thinking or both This study may provide a new framework to explain the relationship between motor and cognitive aspects of human behavior and help to clarify the pathophysiology of Parkinsons disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0024 | None | None | None |