Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00021840
Status:
COMPLETED
Last Update Posted:
2014-08-04
First Post:
2001-08-07
Brief Title:
Genetic Epidemiology of Asthma in Costa Rica
Sponsor:
Brigham and Womens Hospital
Organization:
Brigham and Womens Hospital
Study Overview
Official Title:
Genetic Epidemiology of Asthma in Costa Rica
Status:
COMPLETED
Status Verified Date:
2014-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify genetic factors that influence the development of asthma in Hispanics
Detailed Description:
BACKGROUND
Asthma is a major public health problem in the United States with particularly high prevalence rates among some Hispanic groups Genetic linkage studies of this disease are of potentially great utility for the identification of those at risk the search for new pharmaceutical treatments and designing interventions to prevent development of asthma Study power is greatly enhanced if a relatively isolated homogeneous population with a significant prevalence of asthma can be identified Such a population does not exist among Hispanics in the United States but is available in the Central Valley of Costa Rica
DESIGN NARRATIVE
The study concentrates on a genetically isolated Hispanic population with high asthma prevalence living in the Central Valley of Costa Rica A genome screen will be conducted on large pedigrees multiplex for asthma and linkage analysis performed for seven intermediate phenotypes related to asthma including airway responsiveness FEV1 bronchodilator responsiveness skin test reactivity to common aeroallergens serum total and allergen-specific IgE and peripheral blood eosinophil count A genome screen will also be conducted in the parent-child trios and ancestral haplotypes will be reconstructed to identify regions influencing asthma-associated phenotypes Within candidate regions demonstrating both linkage in extended pedigrees to asthma andor asthma-related phenotypes and significant linkage disequilibrium within the unrelated asthmatic subjects fine mapping will be performed by testing for genetic association to single nucleotide polymorphisms within positional candidate genes
Asthma is a major public health problem in the United States with particularly high prevalence rates among some Hispanic groups Genetic linkage studies of this disease are of potentially great utility for the identification of those at risk the search for new pharmaceutical treatments and designing interventions to prevent development of asthma Study power is greatly enhanced if a relatively isolated homogeneous population with a significant prevalence of asthma can be identified Such a population does not exist among Hispanics in the United States but is available in the Central Valley of Costa Rica
DESIGN NARRATIVE
The study concentrates on a genetically isolated Hispanic population with high asthma prevalence living in the Central Valley of Costa Rica A genome screen will be conducted on large pedigrees multiplex for asthma and linkage analysis performed for seven intermediate phenotypes related to asthma including airway responsiveness FEV1 bronchodilator responsiveness skin test reactivity to common aeroallergens serum total and allergen-specific IgE and peripheral blood eosinophil count A genome screen will also be conducted in the parent-child trios and ancestral haplotypes will be reconstructed to identify regions influencing asthma-associated phenotypes Within candidate regions demonstrating both linkage in extended pedigrees to asthma andor asthma-related phenotypes and significant linkage disequilibrium within the unrelated asthmatic subjects fine mapping will be performed by testing for genetic association to single nucleotide polymorphisms within positional candidate genes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R37HL066289 | NIH | None | httpsreporternihgovquickSearchR37HL066289 |