Ignite Creation Date:
2024-05-05 @ 9:25 PM
Last Modification Date:
2024-10-26 @ 10:04 AM
Study NCT ID:
NCT00883597
Status:
COMPLETED
Last Update Posted:
2022-03-08
First Post:
2009-04-16
Brief Title:
Sidestream Dark-Field SDF Imaging of the Intestinal Microcirculation
Sponsor:
Christian Lehmann
Organization:
Nova Scotia Health Authority
Study Overview
Official Title:
Sidestream Dark-Field Imaging of the Intestinal Microcirculation in Clinical Sepsis The Impact of Activated Protein C Therapy
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sepsis is the most frequent cause of death in critically ill patients in non-coronary care Intensive Care Units in the developed world Microcirculatory disturbances are central to the development of the disorder leading to organ dysfunction multi-organ failure and fatal outcome
In particular the intestinal microcirculation is impaired early in the course of the disease This may result in a breakdown of the gut barrier function with translocation of bacteria and their toxins into the systemic circulation thus sustaining a gut derived septic state Therefore the impaired intestinal microcirculation has been suggested to act as the motor of multiple organ failure in sepsis
The aim of the project is to evaluate a new diagnostic tool and the impact of Activated Protein C administration on the intestinal microcirculation in patients with severe sepsis and compare the findings with septic patients who are not candidates for APC therapy and healthy patients post bowel surgery using an innovative diagnostic tool side stream dark-field imaging SDF
In particular the intestinal microcirculation is impaired early in the course of the disease This may result in a breakdown of the gut barrier function with translocation of bacteria and their toxins into the systemic circulation thus sustaining a gut derived septic state Therefore the impaired intestinal microcirculation has been suggested to act as the motor of multiple organ failure in sepsis
The aim of the project is to evaluate a new diagnostic tool and the impact of Activated Protein C administration on the intestinal microcirculation in patients with severe sepsis and compare the findings with septic patients who are not candidates for APC therapy and healthy patients post bowel surgery using an innovative diagnostic tool side stream dark-field imaging SDF
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None