Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00029601
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-01-15
Brief Title:
Surround Inhibition in Patients With Dystonia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Study of Surround Inhibition in Patients With Dystonia
Status:
COMPLETED
Status Verified Date:
2002-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation TMS to examine how the brain controls muscle movement in dystonia Dystonia is a movement disorder in which involuntary muscle contractions cause uncontrolled twisting and repetitive movement or abnormal postures Dystonia may be focal involving just one region of the body such as the hand neck or face Focal dystonia usually begins in adulthood Generalized dystonia on the other hand generally begins in childhood or adolescence Symptoms begin in one area and then become more widespread
Healthy normal volunteers and patients with focal or generalized dystonia between 21 and 65 years of age may be eligible for this study
Participants will have transcranial magnetic stimulation For this test subjects are seated in a comfortable chair with their hands placed on a pillow on their lap An insulated wire coil is placed on the scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain This may cause muscle hand or arm twitching if the coil is near the part of the brain that controls movement or it may induce twitches or transient tingling in the forearm head or face muscles During the stimulation subjects will be asked to either keep their hand relaxed or move a certain part of the hand in response to a loud beep or visual cue Metal electrodes will be taped to the skin over the muscle for computer recording of the electrical activity of the hand and arm muscles activated by the stimulation
There are three parts to the study each lasting 2-3 hours and each performed on a separate day
Healthy normal volunteers and patients with focal or generalized dystonia between 21 and 65 years of age may be eligible for this study
Participants will have transcranial magnetic stimulation For this test subjects are seated in a comfortable chair with their hands placed on a pillow on their lap An insulated wire coil is placed on the scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain This may cause muscle hand or arm twitching if the coil is near the part of the brain that controls movement or it may induce twitches or transient tingling in the forearm head or face muscles During the stimulation subjects will be asked to either keep their hand relaxed or move a certain part of the hand in response to a loud beep or visual cue Metal electrodes will be taped to the skin over the muscle for computer recording of the electrical activity of the hand and arm muscles activated by the stimulation
There are three parts to the study each lasting 2-3 hours and each performed on a separate day
Detailed Description:
The purpose of this study is to evaluate modulation of inhibition within the motor cortex before and during movement in patients with focal dystonia For a selective movement or task certain muscles are normally recruited and others are inhibited at the cortical level We hypothesize that a disturbance in this cortical inhibitory control could result in a failure to focus the desired motor action within the motor cortex disturbed center surround inhibition and may account for co-contraction of antagonist muscles and overflow into extraneous muscles in dystonic patients Intracortical inhibition ICI and silent period SP are two major cortical inhibitory mechanisms demonstrated by transcranial magnetic stimulation TMS Alteration in these inhibitory mechanisms have been studied in dystonia at rest however as dystonic symptoms mainly occur with selective tasks or movements we plan to study intracortical inhibitory mechanisms before and during movement using different TMS paradigms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0088 | None | None | None |