Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00030199
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-02-07
Brief Title:
Brain Control of Blinking
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Cortical Control of Voluntary Blinking
Status:
COMPLETED
Status Verified Date:
2004-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation TMS to study how the brain controls movement of muscles in the face-in particular those involved in eye blinking TMS is a procedure that activates areas of the brain with magnetic pulses that travel through the scalp and the skull
Healthy normal volunteers 21 years of age and older may be eligible for this study They must be free of any serious medical illness have no neurological or psychiatric disorders or history of seizures and must not be taking any medications that can affect nervous system function
Participants will undergo TMS and the electrical activity in muscles activated by the stimulation will be recorded For TMS an insulated wire coil is placed on the patients scalp and a brief electrical current is passed through the coil This creates a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain If the coil is placed over a nerve that controls muscles there may be a twitch in the muscles sometimes large enough to move the face In other cases there may be a feeling of movement or tingling sensation in the face Stimulation over the muscles on the side of the head may cause some discomfort there or twitching of the jaw During the stimulation subjects may be asked to tense certain muscles slightly or perform other simple actions
Electrical activity of the muscles activated by the stimulation is recorded This is done with both metal electrodes taped to the skin over the muscle and with fine needle electrodes inserted into the muscles around the eyes
The study usually takes less than 3 hours with frequent breaks If more time is required the study will be broken into more than one session
Healthy normal volunteers 21 years of age and older may be eligible for this study They must be free of any serious medical illness have no neurological or psychiatric disorders or history of seizures and must not be taking any medications that can affect nervous system function
Participants will undergo TMS and the electrical activity in muscles activated by the stimulation will be recorded For TMS an insulated wire coil is placed on the patients scalp and a brief electrical current is passed through the coil This creates a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain If the coil is placed over a nerve that controls muscles there may be a twitch in the muscles sometimes large enough to move the face In other cases there may be a feeling of movement or tingling sensation in the face Stimulation over the muscles on the side of the head may cause some discomfort there or twitching of the jaw During the stimulation subjects may be asked to tense certain muscles slightly or perform other simple actions
Electrical activity of the muscles activated by the stimulation is recorded This is done with both metal electrodes taped to the skin over the muscle and with fine needle electrodes inserted into the muscles around the eyes
The study usually takes less than 3 hours with frequent breaks If more time is required the study will be broken into more than one session
Detailed Description:
The purpose of this study is to investigate the cortical center for voluntary control of eyelid closure using transcranial magnetic stimulation TMS Conventionally the primary motor cortex M1 has been thought to control upper facial movement However recent neuroanatomical and neuroimaging studies suggest that the upper facial muscles are mainly controlled by the mesial frontal region not M1 Recently we performed a transcranial magnetic stimulation TMS study to investigate the cortical center for the upper facial muscles especially those related to blinking and observed possible cortical responses from the surface electrodes attached to the orbicularis oculi OOC muscles with the stimulation applied to the mesial frontal region In this study we are planning to use monopolar needle electrodes to confirm that these responses originate from the cortical stimulation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0119 | None | None | None |