Ignite Creation Date:
2024-05-05 @ 9:27 AM
Last Modification Date:
2024-10-26 @ 9:01 AM
Study NCT ID:
NCT00000294
Status:
COMPLETED
Last Update Posted:
2017-01-12
First Post:
1999-09-20
Brief Title:
Effects of Carvedilol on Cocaine Use in Humans - 11
Sponsor:
National Institute on Drug Abuse NIDA
Organization:
National Institute on Drug Abuse NIDA
Study Overview
Official Title:
Effects of Carvedilol on Cocaine Use in Humans
Status:
COMPLETED
Status Verified Date:
1999-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine carvedilol effects in response to cocaine
Detailed Description:
The purpose of this study was to determine whether carvedilol and alpha and beta adrenergic blocker would inhibit the priming effect of cocaine in a laboratory model A total of 12 subjects were enrolled in this double blind placebo controlled outpatient study After an adaptation session three experimental sessions were held 2-9 days apart On each of 3 experimental sessions a single oral dose of low 25mg or high dose of carvedilol 50mg or placebo were administered Two hours following carvedilol or placebo treatment subjects received a priming dose of smoked cocaine 04 mgkg during the second part of the session subjects had the option to earn up to 2 tokens by working on a computer task that could later be exchanged for money or deliveries of cocaine We proposed that blockage of adrenergic receptors by carvedilol would significantly alter the subjective and physiological effects of cocaine
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P50-09259-11 | None | None | None |