Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006336
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-10-04
Brief Title:
Sensory Training to Treat Focal Dystonia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Sensory Training for Treatment of Focal Dystonia
Status:
COMPLETED
Status Verified Date:
2001-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the effectiveness of Braille reading as a sensory training program for improving symptoms of focal localized dystonia a movement disorder caused by sustained muscle contractions Musicians writers typists athletes and others whose work involves frequent repetitive movements may develop focal dystonia of the hand Dystonia patients have an impaired sense of touch and it is thought that symptoms may improve with sensory tactile touch training
Patients with task-specific dystonia and healthy normal volunteers may be eligible for this 8-week study Patients will undergo evaluation of their dystonia and a complete neurologic examination Healthy volunteers will have a complete physical examination
On the first day of the study after 4 weeks and after 8 weeks all participants will have a gap detection test for sensory perception testing The test uses eight plastic devices called JVP-Domes with ridges of different widths on the surface The subjects arm and hand are held in palm-up position and the right index finger is tested for about 1 second 20 times with each dome The subject is asked to report whether the direction of the dome is vertical or horizontal The test takes about 30 minutes Patients with dystonia will also have a their symptoms evaluated at these visits The evaluation involves completing a written questionnaire and writing a paragraph
All participants will be trained in Braille reading at NIH Sessions will be given every day the first week twice a week the second and third weeks and once a week the following weeks
Patients with task-specific dystonia and healthy normal volunteers may be eligible for this 8-week study Patients will undergo evaluation of their dystonia and a complete neurologic examination Healthy volunteers will have a complete physical examination
On the first day of the study after 4 weeks and after 8 weeks all participants will have a gap detection test for sensory perception testing The test uses eight plastic devices called JVP-Domes with ridges of different widths on the surface The subjects arm and hand are held in palm-up position and the right index finger is tested for about 1 second 20 times with each dome The subject is asked to report whether the direction of the dome is vertical or horizontal The test takes about 30 minutes Patients with dystonia will also have a their symptoms evaluated at these visits The evaluation involves completing a written questionnaire and writing a paragraph
All participants will be trained in Braille reading at NIH Sessions will be given every day the first week twice a week the second and third weeks and once a week the following weeks
Detailed Description:
It has been hypothesized that dystonia may be a sensory disorder Animal studies as well as physiological studies of patients with focal dystonia have demonstrated sensory dysfunction It has also been shown that patients with dystonia have impaired sensory perception including when assessed with the JVP gap detection test This could possibly result from enlargement and dedifferentiation of representations in the sensory cortex We therefore hypothesize that sensory training could improve the impaired sensory perception and hence improve the dystonia This study will examine if Braille reading as a sensory training program can correct the sensory perception and the dystonia The primary outcome is improvement in the JVP gap detection test
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-N-0227 | None | None | None |