Ignite Creation Date:
2025-12-26 @ 2:38 PM
Ignite Modification Date:
2025-12-26 @ 2:38 PM
Study NCT ID:
NCT03137706
Status:
TERMINATED
Last Update Posted:
2021-04-05
First Post:
2017-04-29
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or Colon Cancer
Sponsor:
University of Southern California
Organization:
Study Overview
Official Title:
Characterization of Mechanical Tissue Properties in Pancreas, Liver and Colon
Status:
TERMINATED
Status Verified Date:
2021-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Insufficient accrual
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This pilot research trial studies characterization of mechanical tissue properties in patients with pancreatic, liver, or colon cancer. Mechanical properties and stiffness of the cancerous tissue may be correlated with the standard pathology report that describes the stage of the disease.
Detailed Description:
PRIMARY OBJECTIVES:
I. To determine if our optical polarimeter device is able to measure tissue stiffness across several human cancer types ex vivo.
SECONDARY OBJECTIVES:
I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine if the measurements made by the optical polarimeter device are non-destructive.
TERTIARY OBJECTIVES:
I. Perform multi-variable cross-correlation statistical analysis to determine relationships between: tissue stiffness characteristics, molecular level signatures, and cellular level properties, and if numbers permit, response to treatment.
OUTLINE:
Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using an optical polarimeter device and cell viability using an automated cell counter.
I. To determine if our optical polarimeter device is able to measure tissue stiffness across several human cancer types ex vivo.
SECONDARY OBJECTIVES:
I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine if the measurements made by the optical polarimeter device are non-destructive.
TERTIARY OBJECTIVES:
I. Perform multi-variable cross-correlation statistical analysis to determine relationships between: tissue stiffness characteristics, molecular level signatures, and cellular level properties, and if numbers permit, response to treatment.
OUTLINE:
Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using an optical polarimeter device and cell viability using an automated cell counter.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| NCI-2016-01955 | REGISTRY | CTRP (Clinical Trial Reporting Program) | View | |
| 0S-16-1 | OTHER | USC / Norris Comprehensive Cancer Center | View | |
| P30CA014089 | NIH | None | https://reporter.nih.gov/quic… | View |