Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00049920
Status:
COMPLETED
Last Update Posted:
2016-07-29
First Post:
2002-11-14
Brief Title:
The ARIC MRI Study
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
The ARIC Neurocognitive Longitudinal Study
Status:
COMPLETED
Status Verified Date:
2008-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To perform a follow-up study of cerebrovascular disease in the Atherosclerosis Risk in Communities ARIC magnetic resonance imaging subcohort
Detailed Description:
BACKGROUND
Although the clinical manifestations of cerebrovascular disease CVD typically appear acutely the deleterious effects of CVD on brain structure and function likely begin in a presymptomatic fashion at a younger age than clinical strokes In an effort to characterize the prevalence risk factors and cognitive correlates of subclinical CVD the Atherosclerosis Risk in Communities ARIC Study funded by the National Heart Lung and Blood Institute performed cerebral magnetic resonance imaging MRI and cognitive assessments on a large bi-racial sample of middle-aged and young-elderly adults Results from the ARIC MRI baseline study revealed a remarkably high prevalence of subclinical CVD including silent cerebral infarctions white matter hyperintensities and brain atrophy Moreover these subclinical abnormalities were found to be associated with reduced cognitive functioning and with clinical CVD outcomes such as incident stroke Surprisingly little is known about risk factors related to the incidence or progression of subclinical CVD or how progression of these markers may relate to clinical outcomes such as stroke or neurocognitive decline
DESIGN NARRATIVE
This is a follow-up study of the ARIC MRI cohort with repeated semiquantitative MR imaging and cognitive assessments The study will also take advantage of recent advances in MR imaging and obtain volumetric measurements of selected brain regions and expand upon the baseline cognitive assessment to further characterize neurocognitive functioning The longitudinal design of the proposed study will fill salient gaps in current understanding of subclinical CVD Moreover conducting this study within ARIC takes advantage of ARICs baseline MRI data unique African American population and extensive vascular risk factor data including new genetic and biochemical factors as well as subclinical markers of both large and small vessel disease making an efficient study to provide new insights into the incidence progression and outcomes associated with subclinical CVD
Although the clinical manifestations of cerebrovascular disease CVD typically appear acutely the deleterious effects of CVD on brain structure and function likely begin in a presymptomatic fashion at a younger age than clinical strokes In an effort to characterize the prevalence risk factors and cognitive correlates of subclinical CVD the Atherosclerosis Risk in Communities ARIC Study funded by the National Heart Lung and Blood Institute performed cerebral magnetic resonance imaging MRI and cognitive assessments on a large bi-racial sample of middle-aged and young-elderly adults Results from the ARIC MRI baseline study revealed a remarkably high prevalence of subclinical CVD including silent cerebral infarctions white matter hyperintensities and brain atrophy Moreover these subclinical abnormalities were found to be associated with reduced cognitive functioning and with clinical CVD outcomes such as incident stroke Surprisingly little is known about risk factors related to the incidence or progression of subclinical CVD or how progression of these markers may relate to clinical outcomes such as stroke or neurocognitive decline
DESIGN NARRATIVE
This is a follow-up study of the ARIC MRI cohort with repeated semiquantitative MR imaging and cognitive assessments The study will also take advantage of recent advances in MR imaging and obtain volumetric measurements of selected brain regions and expand upon the baseline cognitive assessment to further characterize neurocognitive functioning The longitudinal design of the proposed study will fill salient gaps in current understanding of subclinical CVD Moreover conducting this study within ARIC takes advantage of ARICs baseline MRI data unique African American population and extensive vascular risk factor data including new genetic and biochemical factors as well as subclinical markers of both large and small vessel disease making an efficient study to provide new insights into the incidence progression and outcomes associated with subclinical CVD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL070825 | NIH | None | httpsreporternihgovquickSearchR01HL070825 |