Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00049868
Status:
COMPLETED
Last Update Posted:
2020-09-25
First Post:
2002-11-14
Brief Title:
Enhanced Linkage Maps From Family-Based Genetics Studies
Sponsor:
Rutgers University
Organization:
Rutgers The State University of New Jersey
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2020-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To develop genetic maps for the genome-wide screening markers used by multiple investigators and to investigate map differences between sexes and different ethnic groups
Detailed Description:
BACKGROUND
Meiotic linkage maps are the foundation of both linkage and linkage disequilibrium studies for mapping disease genes Despite the importance of precise maps existing genome-wide linkage maps were built using only a small collection of pedigrees and so have wide confidence intervals surrounding estimates of map distance Incorrect marker order and map distances can have a profound effect on linkage analyses Using a sex-averaged map instead of a sex-specific map biases the lod scores upward markedly increasing the false positive rate Since it is very costly to follow-up many false-positive results there is a clear need for more precise and accurate sex-specific genetic maps Accurate estimates of meiotic map distance cannot be obtained by any means other than by linkage analysis using genotype data
The study is in response to a Request for Applications entitled NHLBI Innovative Research Grant Program released in July 2001 The purpose of the initiative is to support new approaches to heart lung and blood diseases and sleep disorders that use existing data sets or existing biological specimen collections whether obtained through National Heart Lung and Blood Institute support or not
DESIGN NARRATIVE
The genetic epidemiology study will build improved highly-precise sex-specific linkage maps utilizing thousands of individuals who have previously been genotyped After filtering out obvious relationship and genotype errors the study will incorporate methods that properly model for genotyping errors In addition to creating precise maps for the scientific community the study will also use these genotype data to study how recombination may vary between ethnic groups The genotypes generated by the NHLBI Mammalian Genotyping Service are precisely the type of data required to produce more accurate maps These data collections contain over 3400 pedigrees with more than a 100-fold increase in information compared to that contained in the 8 CEPH families that have been used to construct current genome-wide linkage maps The new maps will be made publicly available and the genotype data from the study will be accessible by the MAP-0-MAT linkage mapping server In the future the study will be broadened to incorporate genotype data from additional genotyping centers such as the Center for Inherited Disease Research CIDR
Meiotic linkage maps are the foundation of both linkage and linkage disequilibrium studies for mapping disease genes Despite the importance of precise maps existing genome-wide linkage maps were built using only a small collection of pedigrees and so have wide confidence intervals surrounding estimates of map distance Incorrect marker order and map distances can have a profound effect on linkage analyses Using a sex-averaged map instead of a sex-specific map biases the lod scores upward markedly increasing the false positive rate Since it is very costly to follow-up many false-positive results there is a clear need for more precise and accurate sex-specific genetic maps Accurate estimates of meiotic map distance cannot be obtained by any means other than by linkage analysis using genotype data
The study is in response to a Request for Applications entitled NHLBI Innovative Research Grant Program released in July 2001 The purpose of the initiative is to support new approaches to heart lung and blood diseases and sleep disorders that use existing data sets or existing biological specimen collections whether obtained through National Heart Lung and Blood Institute support or not
DESIGN NARRATIVE
The genetic epidemiology study will build improved highly-precise sex-specific linkage maps utilizing thousands of individuals who have previously been genotyped After filtering out obvious relationship and genotype errors the study will incorporate methods that properly model for genotyping errors In addition to creating precise maps for the scientific community the study will also use these genotype data to study how recombination may vary between ethnic groups The genotypes generated by the NHLBI Mammalian Genotyping Service are precisely the type of data required to produce more accurate maps These data collections contain over 3400 pedigrees with more than a 100-fold increase in information compared to that contained in the 8 CEPH families that have been used to construct current genome-wide linkage maps The new maps will be made publicly available and the genotype data from the study will be accessible by the MAP-0-MAT linkage mapping server In the future the study will be broadened to incorporate genotype data from additional genotyping centers such as the Center for Inherited Disease Research CIDR
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL071029 | NIH | None | httpsreporternihgovquickSearchR01HL071029 |