Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00048100
Status:
TERMINATED
Last Update Posted:
2018-10-31
First Post:
2002-10-24
Brief Title:
Anti-Leukemic Dendritic Cell Activated Donor Lymphocytes
Sponsor:
MD Anderson Cancer Center
Organization:
MD Anderson Cancer Center
Study Overview
Official Title:
Anti-Leukemic Dendritic Cell Activated Donor Lymphocytes for Therapy of Relapsed Leukemia After Allogeneic Stem Cell Therapy
Status:
TERMINATED
Status Verified Date:
2018-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Slow accrual
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objectives
1 Determine the toxicity of infusions of allogeneic donor lymphocytes activated by acute leukemia derived dendritic cells DCADL in relapsed patients after allo-stem cell transplants
2 Quantitate the alloreactivity of DCADL and circulating immune effector cells in patients after infusion
3 Assess efficacy of acute myelogenous leukemia AML or Chronic Myelogenous Leukemia in Blastic Crisis CML-BC derived dendritic cells and activated lymphocytes in promoting and sustaining remission in patients with relapse after allo-BMT or stem cell transplant
1 Determine the toxicity of infusions of allogeneic donor lymphocytes activated by acute leukemia derived dendritic cells DCADL in relapsed patients after allo-stem cell transplants
2 Quantitate the alloreactivity of DCADL and circulating immune effector cells in patients after infusion
3 Assess efficacy of acute myelogenous leukemia AML or Chronic Myelogenous Leukemia in Blastic Crisis CML-BC derived dendritic cells and activated lymphocytes in promoting and sustaining remission in patients with relapse after allo-BMT or stem cell transplant
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None