Ignite Creation Date:
2025-12-24 @ 11:44 PM
Ignite Modification Date:
2025-12-25 @ 9:37 PM
Study NCT ID:
NCT01936051
Status:
COMPLETED
Last Update Posted:
2019-04-08
First Post:
2013-08-27
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients
Sponsor:
Seoul National University Hospital
Organization:
Study Overview
Official Title:
Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients
Status:
COMPLETED
Status Verified Date:
2019-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To modeling the pharmacokinetic-pharmacodynamic(PK-PD) simulation with the plasma concentration and the transporter occupancy from OCD patients treated with escitalopram.
To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram.
To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram.
Detailed Description:
To measure plasma concentration of escitalopram in OCD patients treated with escitalopram.
To measure serotonin transporter occupancy by escitalopram in OCD patients treated with escitalopram.
To genotype G2677T/A SNP of ABCB1 gene in OCD patients treated with escitalopram.
To measure serotonin transporter occupancy by escitalopram in OCD patients treated with escitalopram.
To genotype G2677T/A SNP of ABCB1 gene in OCD patients treated with escitalopram.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| 2011-0931 | OTHER | Seoul National university Hospital IRB | View |