Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005388
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Visceral Fat Metabolic Rate and CHD Risk in Young Adults
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To measure visceral intraabdominal fat by computerized tomography CT scan and to measure resting metabolic rate by indirect calorimetry in 400 CARDIA subjects ages 28-40 years 100 of each racegender group from the Oakland California and Birmingham Alabama centers
Detailed Description:
BACKGROUND
The prevalence of obesity increased markedly in the United States from the 1960s to the 1980s and varied by race and gender with particularly high rates of obesity among Black women Reasons for the ethnic differences in the prevalence of obesity were not understood This cross-sectional study was performed in conjunction with the 10-year follow-up examination for the Coronary Artery Risk Development in Young Adults CARDIA study an NHLBI-funded longitudinal study of development of risk factors for coronary heart disease CHD in young black and white adults
This study represented a unique opportunity to investigate factors that may influence the development of obesity to better understand the relationship between obesity and cardiovascular risk factors and to increase understanding of racial differences in adiposity
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
DESIGN NARRATIVE
The cross-sectional study tested the hypothesis that visceral adipose tissue the component of fat considered to be most strongly related to coronary heart disease CHD risk factors differed in Black and white subjects Specifically the investigators proposed that Black subjects had less visceral adipose tissue for a given level of total body fat than white subjects Further the relationship between visceral adipose tissue and risk factors for CHD was similar in all subjects This would explain the different relationship between obesity and CHD risk factors seen in Black vs white subjects A second specific aim was to determine whether Black women had a lower resting energy expenditure than Black men or whites This could explain the higher prevalence of obesity in Black women than in Black men or whites of either gender CT scans were recorded on tape and shipped to the University of Colorado Health Sciences Center where visceral adipose tissue was quantified Dietary intake and physical activity were measured as important covariates in the relationship between metabolic rate and adiposity and thyroid function was measured as a determinant of resting energy expenditure The CARDIA study provided funding for cardiovascular risk factor measurements including blood pressure lipids insulin glucose smoking and anthropometric measurements including dual energy absorptiometry DEXA measurements of total and regional body fat
The study was renewed in 1999 through March 2004 to perform a five-year follow-up of the cohort
The prevalence of obesity increased markedly in the United States from the 1960s to the 1980s and varied by race and gender with particularly high rates of obesity among Black women Reasons for the ethnic differences in the prevalence of obesity were not understood This cross-sectional study was performed in conjunction with the 10-year follow-up examination for the Coronary Artery Risk Development in Young Adults CARDIA study an NHLBI-funded longitudinal study of development of risk factors for coronary heart disease CHD in young black and white adults
This study represented a unique opportunity to investigate factors that may influence the development of obesity to better understand the relationship between obesity and cardiovascular risk factors and to increase understanding of racial differences in adiposity
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
DESIGN NARRATIVE
The cross-sectional study tested the hypothesis that visceral adipose tissue the component of fat considered to be most strongly related to coronary heart disease CHD risk factors differed in Black and white subjects Specifically the investigators proposed that Black subjects had less visceral adipose tissue for a given level of total body fat than white subjects Further the relationship between visceral adipose tissue and risk factors for CHD was similar in all subjects This would explain the different relationship between obesity and CHD risk factors seen in Black vs white subjects A second specific aim was to determine whether Black women had a lower resting energy expenditure than Black men or whites This could explain the higher prevalence of obesity in Black women than in Black men or whites of either gender CT scans were recorded on tape and shipped to the University of Colorado Health Sciences Center where visceral adipose tissue was quantified Dietary intake and physical activity were measured as important covariates in the relationship between metabolic rate and adiposity and thyroid function was measured as a determinant of resting energy expenditure The CARDIA study provided funding for cardiovascular risk factor measurements including blood pressure lipids insulin glucose smoking and anthropometric measurements including dual energy absorptiometry DEXA measurements of total and regional body fat
The study was renewed in 1999 through March 2004 to perform a five-year follow-up of the cohort
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL053359 | NIH | None | httpsreporternihgovquickSearchR01HL053359 |