Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00059423
Status:
COMPLETED
Last Update Posted:
2024-03-22
First Post:
2003-04-25
Brief Title:
Natural History Study for BEN
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent
Status:
COMPLETED
Status Verified Date:
2020-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In recent decades hematologists have noticed that persons of African descent sometimes have lower white blood cell counts of a certain type called granulocytes These cells help to fight infections The lower number of granulocytes in this situation does not appear to lead to more infections and these individuals do not have any symptoms This condition is called benign ethnic neutropenia BEN and is observed in a small percentage of individuals of African descent This study will investigate the condition by studying people with and without BEN
The goals of this study are to
1 identify individuals of African descent with BEN
2 determine the effects of two drugs G-CSF and dexamethasone on granulocyte production and movement
3 determine whether there are differences in those with and without BEN in the way genes are stimulated after the administration of G-CSF and dexamethasone
Study participants will be asked to interview with the research team undergo physical exams donate a blood sample and receive G-CSF by injection followed by dexamethasone orally about three weeks later They also will be required to undergo apheresis three times a procedure in which blood is drawn from a donor and separated into its components Some components are retained for research analyses such as granulocytes and small amount of blood the remainder is returned by transfusion to the donor This procedure will be required of participants before they receive G-CSF the day after they receive G-CSF and the day after they receive dexamethasone Gene messages mRNA will be isolated from granulocytes and analyzed to better understand granulocyte growth and movement
The goals of this study are to
1 identify individuals of African descent with BEN
2 determine the effects of two drugs G-CSF and dexamethasone on granulocyte production and movement
3 determine whether there are differences in those with and without BEN in the way genes are stimulated after the administration of G-CSF and dexamethasone
Study participants will be asked to interview with the research team undergo physical exams donate a blood sample and receive G-CSF by injection followed by dexamethasone orally about three weeks later They also will be required to undergo apheresis three times a procedure in which blood is drawn from a donor and separated into its components Some components are retained for research analyses such as granulocytes and small amount of blood the remainder is returned by transfusion to the donor This procedure will be required of participants before they receive G-CSF the day after they receive G-CSF and the day after they receive dexamethasone Gene messages mRNA will be isolated from granulocytes and analyzed to better understand granulocyte growth and movement
Detailed Description:
Benign ethnic neutropenia BEN is defined by peripheral blood absolute neutrophil count less than 15 x 10 9 per liter without an increase in infections This condition has been described in individuals of African descent Although these individuals have normal myeloid maturation on bone marrow examinations they appear to release fewer neutrophils into the circulation when stimulated by hydrocortisone compared to normal controls This suggests that there may be differences in the regulation of neutrophil release or trafficking In the past decade granulocyte-colony stimulating factor G-CSF has been widely used in a variety of clinical settings from patients with chemotherapy-induced neutropenia to normal volunteers for peripheral blood stem cell collection G-CSF however has not been used in individuals with BEN Furthermore gene expression in neutrophil proliferation and trafficking has not been studied in these individuals The purpose of this study are to 1 identify individuals with BEN 2 follow the natural history of BEN 3 determine if there is a familial inheritance pattern 4 characterize and compare neutrophil response to dexamethasone and G-CSF 5 compare the pattern of neutrophil gene expression by microarray analyses and 6 determine if mutations are present at the DNA level to account for gene expression pattern differences in individuals of African descent with and without BEN at baseline post dexamethasone and post G-CSF stimulation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-H-0168 | None | None | None |