Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00008892
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2001-01-18
Brief Title:
Brain Imaging in Children With ADHD
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Anatomic MRI Brain Imaging of White Matter in Children
Status:
COMPLETED
Status Verified Date:
2007-01-31
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to use brain imaging technology to study the connections between brain regions in children with attention deficit hyperactivity disorder ADHD and comparing them to children without ADHD
This study will build upon previous brain imaging studies of healthy volunteers and children who have ADHD This study will use diffusion tensor magnetic resonance imaging DT-MRI to visualize and measure certain parts of the brains of identical twin pairs in which one twin has ADHD combined type
Participants in this study will be screened with questionnaires and interviews psychometric testing and a physical examination Participants medical and educational records may be reviewed Participants will undergo an MRI scan of the brain Prior to the MRI participants will have a training session in a simulated MRI scanner to learn how to lie still during MRI scanning Participants may be asked to return for a follow-up scan in about 2 years
This study will build upon previous brain imaging studies of healthy volunteers and children who have ADHD This study will use diffusion tensor magnetic resonance imaging DT-MRI to visualize and measure certain parts of the brains of identical twin pairs in which one twin has ADHD combined type
Participants in this study will be screened with questionnaires and interviews psychometric testing and a physical examination Participants medical and educational records may be reviewed Participants will undergo an MRI scan of the brain Prior to the MRI participants will have a training session in a simulated MRI scanner to learn how to lie still during MRI scanning Participants may be asked to return for a follow-up scan in about 2 years
Detailed Description:
Attention-deficithyperactivity disorder ADHD is the most common childhood psychiatric disorder present in between 3 to 10 of children in the United States Wender et al 2001 It is thought to reflect subtle anomalies in the central nervous system and thus structural neuroimaging has been used extensively to delineate the neurobiology of the disorder Magnetic resonance imaging has demonstrated structural anomalies in ADHD affecting all the major lobes with particularly severe volume reductions in the cerebellum and relative preservation of the caudate nucleus for a review see Durston 2003 In structural neuroimaging work studies with monozygotic twins who are discordant for the disorder have proved a particularly powerful tool with findings of a significantly smaller caudate nucleus in the affected twin compared to the unaffected but genetically identical twin Castellanos et al 2003 We have previously reported an overall reduction in white matter volume in all four major brain lobes with the deficit appearing to be fixed and non-progressive However recent advances in neuroimaging of white matter make feasible an examination of white matter characteristics such as the degree of myelination and the coherence of white matter tracts The proposed project builds on our anatomic magnetic resonance imaging MRI studies that have been performed with a 15-Tesla scanner in children who have Attention-DeficitHyperactivity Disorder ADHD and normal controls We now propose to use diffusion tensor magnetic resonance imaging DT-MRI as conventional T1- and T2-weighted images at 3-Tesla to visualize and quantify white matter tracts in the brains of normal monozygotic MZ twins MZ twins who are concordant for ADHD and MZ twins who are discordant for ADHD Ages will range from 6 to 21 years Our principal focus will be on development and possible abnormalities of white matter tracts linking prefrontal-striatal-thalamic circuits in which we hypothesize disruption of these tracts in affected twins relative to their healthy co-twins We will also explore the usefulness of this technique in delineating white matter in cerebellar circuits and characterize the normal development of white matter from ages 6 to 21 by using a single healthy twin per family
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-M-0064 | None | None | None |