Ignite Creation Date:
2024-05-04 @ 6:49 PM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005184
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Immunogenetic Factors of Coronary Heart Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To assess the association of immunogenetic factors with onset of coronary heart disease and the interrelationship of these factors with standard coronary heart disease risk factors
Detailed Description:
BACKGROUND
Although the familial clustering of coronary heart disease has been well documented it is unclear as to whether the familial clustering can be explained by shared environmental factors by members of a family or by clustering of risk factors having a genetic component such as blood pressure familial hyperlipidemia andor diabetes Studies indicate that a family history of coronary disease may be an independent risk factor Major histocompatibility complex genetic markers to identify individuals at risk within a family may be useful In 1985 when the study began there was a paucity of data dealing with the interrelationship of family history genetic markers immunological markers and traditional risk factors
DESIGN NARRATIVE
In this case-control study the study population consisted of incident cases who presented to the Georgia Heart Clinic in La Grange Georgia with coronary heart disease The majority of the subjects were from three counties in mideastern Alabama and from counties in midwestern Georgia All subjects had undergone diagnostic coronary angiography A determination was made in patients and controls of the association of major histocompatibility complex genetic markers HLA-A -B -C -DR C4 and BF C3 the restriction fragment length polymorphisms RFLPs flanking the apolipoprotein AI and insulin genes presence of autoantibodies and family history of coronary disease diabetes or hypothyroidism The frequency of these variables was compared with the standard coronary risk factors of family history hypertension lipid abnormalities lifestyle Type A behavior obesity and with diseases such as diabetes and hypothyroidism An analysis was made of the strength of these variables for predicting those individuals at risk and whether there were variables which predict severity of disease based on 1 2 or 3 vessel involvement
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Although the familial clustering of coronary heart disease has been well documented it is unclear as to whether the familial clustering can be explained by shared environmental factors by members of a family or by clustering of risk factors having a genetic component such as blood pressure familial hyperlipidemia andor diabetes Studies indicate that a family history of coronary disease may be an independent risk factor Major histocompatibility complex genetic markers to identify individuals at risk within a family may be useful In 1985 when the study began there was a paucity of data dealing with the interrelationship of family history genetic markers immunological markers and traditional risk factors
DESIGN NARRATIVE
In this case-control study the study population consisted of incident cases who presented to the Georgia Heart Clinic in La Grange Georgia with coronary heart disease The majority of the subjects were from three counties in mideastern Alabama and from counties in midwestern Georgia All subjects had undergone diagnostic coronary angiography A determination was made in patients and controls of the association of major histocompatibility complex genetic markers HLA-A -B -C -DR C4 and BF C3 the restriction fragment length polymorphisms RFLPs flanking the apolipoprotein AI and insulin genes presence of autoantibodies and family history of coronary disease diabetes or hypothyroidism The frequency of these variables was compared with the standard coronary risk factors of family history hypertension lipid abnormalities lifestyle Type A behavior obesity and with diseases such as diabetes and hypothyroidism An analysis was made of the strength of these variables for predicting those individuals at risk and whether there were variables which predict severity of disease based on 1 2 or 3 vessel involvement
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL033959 | NIH | None | httpsreporternihgovquickSearchR01HL033959 |