Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001922
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
1999-11-03
Brief Title:
Sensory Function in Idiopathic Voice Disorders
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Sensory Function in Idiopathic Voice Disorders
Status:
COMPLETED
Status Verified Date:
2009-09-14
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This research study is designed to improve understanding about voice disorders that are due to uncontrolled muscle contractions affecting the voice box The type of voice disorder depends on which muscles of the voice box are involved Abductor spasmodic dysphonia may lead to a weak voice Adductor spasmodic dysphonia may result in a strangled voice Muscular tension dysphonia may lead to a strained voice Some of the major goals of the study are to
1 understand how sensation from the voice box affects voice and speech production
2 develop better ways to diagnose sensation abnormalities affecting the voice box
3 determine if patients with voice disorders differ from persons without voice disorders in the way they respond to sensory information from their voice box
Researchers believe that by understanding better how sensations of the voice box are presented and how the muscles in the larynx respond to those sensations they will be able to develop better treatments for patients suffering from voice disorders
1 understand how sensation from the voice box affects voice and speech production
2 develop better ways to diagnose sensation abnormalities affecting the voice box
3 determine if patients with voice disorders differ from persons without voice disorders in the way they respond to sensory information from their voice box
Researchers believe that by understanding better how sensations of the voice box are presented and how the muscles in the larynx respond to those sensations they will be able to develop better treatments for patients suffering from voice disorders
Detailed Description:
Study Aim One To develop and validate objective procedures for quantifying efferent responses to non-invasive laryngeal mechanical and aerodynamic stimulation
Study Aim Two To develop and validate an objective test of brain stem evoked responses to laryngeal stimulation using electrical stimulation of the superior laryngeal nerve
Study Aim Three To determine whether individuals with idiopathic voice disorders have abnormal conditioning of their responses to laryngeal mechanical and aerodynamic stimulation
Study Aim Four To determine whether individuals with idiopathic voice disorders have abnormal brain stem responses to laryngeal stimuli
Study Aim Five To evaluate whether sensory input plays a role in symptom generation in laryngeal motor control disorders temporary bilateral ISLN blockade will be used in idiopathic voice disorders
Study Aim Six To evaluate whether the central pathophysiology involved in motor responses to sensory stimulation are altered by botulinum toxin injection in individuals with spasmodic dysphonia
Study Aim Seven To evaluate central responses to laryngeal afferent stimulation in normal volunteers and patients with idiopathic voice disorders at rest and during vocalization using magnetoencephalography
These studies will develop improved non-invasive techniques for the diagnosis of laryngeal sensory disorders and will determine if abnormalities in sensory feedback modulation are involved in idiopathic voice disorders Such findings will lead to improved understanding of the pathophysiology and differential diagnosis of idiopathic voice disorders and may ultimately improve treatment approaches to these disorders
Study Aim Two To develop and validate an objective test of brain stem evoked responses to laryngeal stimulation using electrical stimulation of the superior laryngeal nerve
Study Aim Three To determine whether individuals with idiopathic voice disorders have abnormal conditioning of their responses to laryngeal mechanical and aerodynamic stimulation
Study Aim Four To determine whether individuals with idiopathic voice disorders have abnormal brain stem responses to laryngeal stimuli
Study Aim Five To evaluate whether sensory input plays a role in symptom generation in laryngeal motor control disorders temporary bilateral ISLN blockade will be used in idiopathic voice disorders
Study Aim Six To evaluate whether the central pathophysiology involved in motor responses to sensory stimulation are altered by botulinum toxin injection in individuals with spasmodic dysphonia
Study Aim Seven To evaluate central responses to laryngeal afferent stimulation in normal volunteers and patients with idiopathic voice disorders at rest and during vocalization using magnetoencephalography
These studies will develop improved non-invasive techniques for the diagnosis of laryngeal sensory disorders and will determine if abnormalities in sensory feedback modulation are involved in idiopathic voice disorders Such findings will lead to improved understanding of the pathophysiology and differential diagnosis of idiopathic voice disorders and may ultimately improve treatment approaches to these disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-N-0009 | None | None | None |