Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00059124
Status:
COMPLETED
Last Update Posted:
2013-07-12
First Post:
2003-04-17
Brief Title:
Aortic Calcium Epidemiology and Progression -- Ancillary to MESA
Sponsor:
University of California San Diego
Organization:
University of California San Diego
Study Overview
Official Title:
Aortic Calcium Epidemiology and Progression
Status:
COMPLETED
Status Verified Date:
2013-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the epidemiology of aortic calcium
Detailed Description:
BACKGROUND
Aortic calcium measured by computed tomography occurs earlier in life than other subclinical that is asymptomatic markers of cardiovascular disease CVD shows a wide range and is common in women The large size of the aorta and relative lack of image artifact from motion make it ideal for radiographic quantitative imaging This study is ancillary to and coordinated with the Multi-Ethnic Study of Atherosclerosis MESA a large prospective epidemiologic study investigating multiple subclinical CVD measures and CVD risk factors Subclinical measures in MESA include coronary calcium carotid ultrasound cardiac magnetic resonance imaging and the anklebrachial blood pressure index The extensive CVD risk factor measurements include both traditional risk factors and newer measures such as inflammatory and genetic markers
DESIGN NARRATIVE
This ancillary study will determine the epidemiology of aortic calcium in 2000 randomly selected from 6500 total MESA participants Questions to be addressed include predictors of aortic calcium progression associations of aortic calcium and aortic calcium progression with other subclinical CVD measures CVD risk factors and demographics and the prognostic significance of aortic calcium The project has three primary specific aims 1 to predict the cross-sectional aortic calcium burden as a function of other subclinical CVD measures and CVD risk factors 2 to predict aortic calcium progression as a function of other subclinical CVD measures and CVD risk factors and 3 to predict aortic calcium progression as a function of progression of selected subclinical CVD measures and CVD risk factors The two secondary specific aims are 1 to contrast the results of the three primary specific aims for men vs women and for four major ethnic groups White Hispanic Black and Asian and 2 to provide a database for future evaluation of whether aortic calcium andor aortic calcium progression independently predict subsequent myocardial infarction stroke and other CVD events
Aortic calcium measured by computed tomography occurs earlier in life than other subclinical that is asymptomatic markers of cardiovascular disease CVD shows a wide range and is common in women The large size of the aorta and relative lack of image artifact from motion make it ideal for radiographic quantitative imaging This study is ancillary to and coordinated with the Multi-Ethnic Study of Atherosclerosis MESA a large prospective epidemiologic study investigating multiple subclinical CVD measures and CVD risk factors Subclinical measures in MESA include coronary calcium carotid ultrasound cardiac magnetic resonance imaging and the anklebrachial blood pressure index The extensive CVD risk factor measurements include both traditional risk factors and newer measures such as inflammatory and genetic markers
DESIGN NARRATIVE
This ancillary study will determine the epidemiology of aortic calcium in 2000 randomly selected from 6500 total MESA participants Questions to be addressed include predictors of aortic calcium progression associations of aortic calcium and aortic calcium progression with other subclinical CVD measures CVD risk factors and demographics and the prognostic significance of aortic calcium The project has three primary specific aims 1 to predict the cross-sectional aortic calcium burden as a function of other subclinical CVD measures and CVD risk factors 2 to predict aortic calcium progression as a function of other subclinical CVD measures and CVD risk factors and 3 to predict aortic calcium progression as a function of progression of selected subclinical CVD measures and CVD risk factors The two secondary specific aims are 1 to contrast the results of the three primary specific aims for men vs women and for four major ethnic groups White Hispanic Black and Asian and 2 to provide a database for future evaluation of whether aortic calcium andor aortic calcium progression independently predict subsequent myocardial infarction stroke and other CVD events
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL072403 | NIH | None | httpsreporternihgovquickSearchR01HL072403 |