Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00061334
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-05-23
Brief Title:
Investigating the Cognitive Processes That Underlie Social Knowledge and Behavior
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Social Knowledge Representation in the Human Prefrontal Cortex
Status:
COMPLETED
Status Verified Date:
2011-12-29
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex Utilizing a variety of experimental neuropsychological tasks during functional MRI we will investigate hypotheses regarding the role of the dorsolateral and ventromedial prefrontal cortex in social cognition and emotional processing We will ascertain the relationship between so-called cold cognition such as event knowledge and hot social cognition such as attitude formation and specific brain regions within the prefrontal cortex We will also attempt to determine the relationship between non-frontal neural structures involved in emotional expressions such as amygdala and those frontal neural structures involved in executive functions that may modulate emotion The data that we collect in this protocol will be of value in 1 identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex and 2 developing functional MRI screening measures for subjects at-risk for developing a neurological disorder We will also use the data obtained in these studies with healthy adult volunteers to constrain theories of frontal lobe function based on the study of patients with focal or diffuse frontal lobe lesions and to provide convergent evidence for the role of specific frontal cortex sectors in specific cognitive functions
Detailed Description:
Objective
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex We suspect that political attitudes can also be viewed as a type of stored knowledge Religious attitudinal and event knowledge are also expected to be similarly represented and stored Utilizing a variety of experimental neuropsychological tasks during functional MRI we will investigate hypotheses regarding the role of the dorsolateral and ventromedial prefrontal cortex in social cognition and emotional processing We will ascertain the relationship between so-called cold cognition such as event knowledge and hot social cognition such as attitude formation and specific brain regions within the prefrontal cortex
Study Population
Normal adult volunteers will participate in experiments dealing with processing of event knowledge general attitudes political stereotypes and attitudes and religious attitudes using fMRI
Design
All the experiments will employ within-subject event-related fMRI design to determine whether activations of different cortical areas correspond to different kind of stored knowledge
Outcome Measures
The data that we collect in this protocol will consist of fMRI activation images corresponding to varying neuropsychological tasks The will be of value in 1 identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex and 2 developing functional MRI screening measures for subjects at-risk for developing a neurological disorder
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex We suspect that political attitudes can also be viewed as a type of stored knowledge Religious attitudinal and event knowledge are also expected to be similarly represented and stored Utilizing a variety of experimental neuropsychological tasks during functional MRI we will investigate hypotheses regarding the role of the dorsolateral and ventromedial prefrontal cortex in social cognition and emotional processing We will ascertain the relationship between so-called cold cognition such as event knowledge and hot social cognition such as attitude formation and specific brain regions within the prefrontal cortex
Study Population
Normal adult volunteers will participate in experiments dealing with processing of event knowledge general attitudes political stereotypes and attitudes and religious attitudes using fMRI
Design
All the experiments will employ within-subject event-related fMRI design to determine whether activations of different cortical areas correspond to different kind of stored knowledge
Outcome Measures
The data that we collect in this protocol will consist of fMRI activation images corresponding to varying neuropsychological tasks The will be of value in 1 identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex and 2 developing functional MRI screening measures for subjects at-risk for developing a neurological disorder
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0196 | None | None | None |