Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00069485
Status:
UNKNOWN
Last Update Posted:
2007-09-18
First Post:
2003-09-26
Brief Title:
Resistance to HIV Infection
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-Exposed Seronegative Individuals
Status:
UNKNOWN
Status Verified Date:
2007-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The immune systems of some individuals may be capable of resisting HIV infection These individuals do not appear to be infected with HIV despite multiple sexual encounters with HIV infected partners This study will examine the immune systems of these individuals to determine what factors are responsible for their ability to resist HIV infection
Study hypothesis Some long-term multiply-exposed seronegative persons have relative resistance to HIV infection maintained by T cell responses
Study hypothesis Some long-term multiply-exposed seronegative persons have relative resistance to HIV infection maintained by T cell responses
Detailed Description:
Rare individuals appear naturally resistant to overt HIV-1 infection despite repeated sexual exposures These individuals referred to as exposed seronegatives ES represent a unique population in which to evaluate mechanisms by which HIV-1 replication is either controlled or aborted The purpose of the study is to analyze HIV-specific immune responses both cellular and humoral that exist in seronegative individuals who have experienced multiple exposures to HIV by sexual contact
This study will follow participants for 2 years Participants will have 25 study visits during the study Assessments will include HIV tests viral load measurements CD4 counts pregnancy tests and physical exams
This study will follow participants for 2 years Participants will have 25 study visits during the study Assessments will include HIV tests viral load measurements CD4 counts pregnancy tests and physical exams
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5R01AI047086-03 | NIH | None | httpsreporternihgovquickSearch5R01AI047086-03 |